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Can Stem Cell Plant-Based be an Alternative to Embryonic …

What is Plant Based Stem Cell Therapy?

Plant based stem cell nutrition are nutritional substances from plants that have been shown to support the release,and activity of your body’s own adult stem cells. This supplement supports wellness by assisting the body in its ability to maintain healthy stem cell physiology, production, and placement. Just as antioxidants are important to protect your cells from free radical damage, stem cell nutrition is equally important to support your stem cells in maintaining proper organ and tissue functioning in your body.

Plant extract stem cell enhancers is the ideal alternative to the embryonic stem cells therapy as ethical concerns have slowed embryonic medical research into applications for stem cells. Also, the embryonic stem cells can unpredictably cause cancer in the treated patient.

The theory that Adult Stem Cells are nothing less than the human body’s natural self-renewal system has profound implications for every area of modern medicine. The idea that heart disease, diabetes, liver degeneration, and other conditions could be things of the past is no longer science fiction; because of recent Adult Stem Cell research breakthroughs, these are real possibilities in the short term.

New research demonstrate that plant based stem cellextract derived from aqua botanical source supports the natural role of adult stem cells. These plant stem cell extracts are typically derived from certain edible algae that grows in fresh water.

When there is an injury or a stress to an organ, compounds are released that reach the bone marrow and trigger the release of stem cells. Stem Cells can be thought of as master cells. Stem cells circulate and function to replace dysfunctional cells, thus fulfilling the natural process of maintaining optimal health

The health benefits of having more stem cells in the blood circulation have been demonstrated by numerous scientific studies. It would be too long here to summarize this vast body of scientific data.I simply suggest you research the work of Dr. Donald Orlic at the National Institute of Health.

Dr. Robert Sampson, MD on stem cell nutrition – “… we have a product that has been shown and demonstrated in the patent to increase the level of adult circulating stem cells by up to 30%. It seems to me we’re having a great opportunity here to optimize the body’s natural ability to create health.”

Stem cells are defined as cells with the unique capacity to self-replicate throughout the entire life of an organism and to differentiate into cells of various tissues. Most cells of the body are specialized and play a well-defined role in the body. For example, brain cells respond to electrical signals from other brain cells and release neurotransmitters; cells of the retina are activated by light, and pancreatic -cells produce insulin. These cells, called somatic cells, will never differentiate into other types of cells or even proliferate. By contrast, stem cells are primitive cells that remain undifferentiated until they receive a signal prompting them to become various types of specialized cells.

Dr. Cliff Minter – “Stem cells are the most powerful cells in the body. We know that stem cells, once they’re circulating in the bloodstream, will travel to any area of the body that has been compromised or damaged and turn into healthy cells. There have been controversial discussions about the new stem cells found in embryos, but the truth is that everyone has adult stem cells in their own bodies. We are all created from stem cells.

As a child or a young adult, your body automatically releases stem cells whenever you injure yourself. That’s why you heal so fast when you are younger. After about age 35, we don’t heal as fast anymore, because the stem cells aren’t released the same way as when we are younger. Stem cell nutrition helps all of us heal our bodies. If you look at the New England Journal of Medicine, you’ll find that the number one indicator of a healthy heart is the number of stem cells circulating in the body. Stem cell nutrition is the organic and all-natural way to stimulate the bone marrow to release adult stem cells into the bloodstream.

By taking stem cell nutrition, you can maintain optimum health and aid your body in healing itself. It’s certainly a better way to recuperate from an illness than using prescription drugs, because even when a medication works, it can often be hard on your liver and the rest of your body. Stem cell nutrition has no negative side effects. This makes it a powerful approach to healing and good health in general.

I found out about stem cell nutrition after someone asked for my opinion on it. I did some research and found it to be one of the greatest ways to slow down aging that we have. Aging is nothing more than the breakdown of cells. Stem cell nutrition combats that action. As cells break down, stem cell nutrition replaces them with healthy cells. This is the greatest, most natural anti-aging method I know. I was skeptical at first, but the results I’ve personally seen in people I’ve talked with have been wide-ranged. Lots of people have reported an increase in energy and better sleeping patterns.

I’ve seen people with arthritis in various parts of their bodies reverse the disease, and people with asthma end up with their lungs totally clear. One person that was on oxygen almost 24/7 is now totally off of oxygen. Two ladies who suffered badly from PMS told me they were 100 percent symptom-free within weeks of starting the stem cell nutrition. Two people I know had tennis elbow which usually takes about six to nine months to heal. Within weeks of taking stem cell nutrition, both report their “tennis elbow” is gone. It makes sense, because stem cells go to whatever area is compromised and turn into healthy cells.

I use stem cell nutrition as a preventative. I’ve noticed an increase in my energy level and an improved sleeping pattern. Stem cell nutrition has zero negative side effects, is very powerful, and we know how it works. It’s good for children as well as adults. This is the best, most natural way I know to optimum health. If you just want to use it for prevention, this is the best thing I know for staying healthy. And if you do those and regaining optimum health. I recommend it to everybody.”

Dr. Cliff Minter (retired) graduated from Illinois College of Podiatric Medicine. He completed his residency at the Hugar Surgery Center in the Hines Veteran Administration Hospital in Illinois before going into private practice in Ventura, CA. Dr. Minter is a national and international speaker on the subjects of business and nutritional products.

The Stem Cell Theory of Renewal proposes that stem cells are naturally released by the bone marrow and travel via the bloodstream toward tissues to promote the body’s natural process of renewal. When an organ is subjected to a process that requires renewal, such as the natural aging process, this organ releases compounds that trigger the release of stem cells from the bone marrow. The organ also releases compounds that attracts stem cells to this organ. The released stem cells then follow the concentration gradient of these compounds and leave the blood circulation to migrate to the organ where they proliferate and differentiate into cells of this organ, supporting the natural process of renewal.

Most of the cells in the human body are specialists assigned to a specific organ or type of tissue, such as the neuronal cells that wire the brain and central nervous system. Stem cells are different. When they divide, they can produce either more stem cells, or they can serve as progenitors that differentiate into specialized cells as they mature. Hence the name, because specialist cells can “stem” from them. The potential to differentiate into specialist cells whose populations in the body have become critically depleted as the result of illness or injury is what makes stem cells so potentially valuable to medical research.

The idea is that if the fate of a batch of stem cells could be directed down specific pathways, they could be grown, harvested, and then transplanted into a problem area. If all went according to plan, these new cells would overcome damaged or diseased cells, leading to healing and recovery. “The life of a stem cell can be viewed as a hierarchical branching process, where the cell is faced with a series of fate switches,” Schaffer says. “Our goal is to identify the cell fate switches, and then provide stem cells with the proper signals toguide them down a particular developmental trajectory.”

Stem cells have the remarkable potential to develop into many different cell types in the body. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function. Scientists believe it should be possible to harness this ability to turn stem cells into a super “repair kit” for the body.

Scientist and author Christian Drapeau explains how the Stem Cell enhancers function to maximize human performance – Supporting the release of stem cells from the bone marrow and increasing the number of circulating stem cells improves various aspects of human health. For very active and sports focused people, Stem Cells are the raw materials to repair micro-tears and micro-injuries created during training. The results, according to Drapeau, are that active people, whether former NBA stars or amateur weekenders, can exercise more intensely at each training session with the ultimate consequence of greater performance.

Theoretically, it should be possible to use stem cells to generate healthy tissue to replace that either damaged by trauma, or compromised by disease. Among the conditions which scientists believe may eventually be treated by stem cell therapy are Parkinson’s disease,Alzheimer’s disease, heart disease, stroke, arthritis, diabetes, burns and spinal cord damage.

Both of my big dogs have gained their youth back. I am a true believer in Stem Cell Nutrition for pets as it has provided a spectacular change in both Ginger and Rowdy. Sonya, IN

Stem cell nutrition for dogs, horses and other animals are specially formulated to be a delectable treat for your animal. The pet chewables and equine blends make it easy to provide your animals with this valuable nutritional supplement. The most common story is that of old, tired and sluggish dogs turned within a week or so into active, alert dogs running around like puppies. The same was observed in horses. Old horses who used to remain standing in the barn or under a tree, sluggish or stricken by too much discomfort to walk around, suddenly began moving about, and at times running and bucking like young colts. One of the most common reports was obvious improvements in hoof health and coat appearance.

times. When there is an injury or a stress to an organ of your beloved pet or horse, compounds are released that reach the bone marrow and trigger the release of stem cells. Stem Cells can be thought of as master cells. Stem cells circulate and function to replace dysfunctional cells, thus fulfilling the natural process of maintaining optimal health.

As they do in humans, adult stem cells reside in animals bone marrow, where they are released whenever there is a problem somewhere in the body. Looking back on stem cell research, we realize that most studies have been done with animals, mostly mice, but also with dogs, horses, pigs, sheep and cattle. These studies have revealed that animal stem cells conduct themselves the same way human stem cells do. When there is an injury or a stress to an organ of your beloved pet or horse, compounds are released that reach the bone marrow and trigger the release of stem cells. The stem cells then travel to tissues and organs in need of help to regain optimal health.

Eve-Marie Lucerne – Eve-Marie keeps nine horses, all older thoroughbreds, and was eager to participate in the trials of a new stem cell enhancer for horses. She shared her allotment of test products with a few large commercial thoroughbred farms, veterinarians and other horse people she knows, and has been pleased with the consistently excellent results she has seen and others have reported to her. This product will help so many animals, she says, adding, People and animals are more alike than we are different. So it makes sense that a stem cell enhancer for animals with promote their health, too.

Eve-Marie’s Equine Stem Cells Nutrition show dramatic results. For several horses facing serious physical challenges, cases where the animals might have to be put down, we saw a return to quality of life. This did not happen before Equine Stem Cell Nutrition. Eve-Marie says that this turnaround was quick, less than two weeks in many cases, and that the subject horses were back to health and enjoying pasture life within a month. One of the unofficial trial subjects for the equine stem cell nutrition was a 30-year old donkey who was in bad shape, Eve-Marie reports. He had chronic respiratory difficulty and could move about only haltingly. His owner had stem cell enhancer supplements to help with her own serious health challenges and shared it with the donkey. The donkey’s owner says this is the first time she wasn’t sick, and her donkey is walking all around, feeling great an enjoying life again!

Farrier and National Hoof practitioner Stephen Dick received some of the trial product from Eve-Marie, and had good results with the two horses he selected for trial. For a 12-year-old quarterhorse stallion, the equine product brought dramatic results. This horse used to lie down twenty-two hours of the day, because he suffered discomfort whenever he stood, Steve reports, continuing, after a couple of weeks with Equine Stem Cell Nutrition, he was getting up and moving around, showing no discomfort. For a high-spirited mare with a leg problem, the equine product brought about a whole new lease on life, Steve says. This horse had been in a stall for 8 months. After about 6 weeks taking the equine product with her grain, her condition had improved and she was out of the stall, walking around in the pasture again.

Little Joe, a small 18-year-old quarter horse that Judy Fisher bought when he was nearly 400 pounds underweight. You could count his ribs, Judy says, remembering, and his backbone stuck up like a ridge all along his back. He was very, very thin! Little Joe also suffered from breathing problems that kept him lethargic and inactive. Vet-recommended remedies were unsuccessful in changing Little Joe’s physical problems, and the vet told Judy he didn’t expect Little Joe to live through the winter. I figured Little Joe was in such bad shape that anything was worth a try, she says.

She began giving the horse stem cell nutrition with his feed and grain twice a day. Within a couple of weeks, Judy was surprised to see Little Joe beginning to gain weight and run, buck, snort and kick. His breathing was no longer labored and his skin and coat were improving. Within six weeks Little Joe’s overall appearance had changed dramatically. He had put on almost 300 pounds. When his former owner came to visit, Judy says, he didn’t recognize Little Joe. That’s how different he looked!

Sara participated in the stem cell nutrition product trials with her two horses and her 80-pound mixed-breed dog. She noted significant improvement in the health and quality of life for all three animals during the time of the trials. For JJ, Sara’s 18-year old quarterhorse, the equine product brought about improvements in his overall mood, appearance and alertness quickly. He really liked the product from the beginning, Sara reports, pointing out that Hank, her 16-year-old thoroughbred/quarterhorse, had not taken to the taste of it too readily. I was able to slowly wean him on it though, she says. For Hank, the equine product was a balm for the skin problems resulting from his allergy to fly bites.

His skin condition improved dramatically. Sara reports, noting that before the equine product the horse had scratched and bitten himself into ope wounds; after the equine product, the scratching and biting dropped off to almost nothing. Sara also noticed an increase in Hank’s energy and liveliness in the first week on the equine product. The horse’s foot and hip discomforts also responded well, leading to a noticeable increase in his mobility and an overall improvement in his quality of life throughout the two-month study.

Sara gave the pet product to her dog, Roxy, who had suffered for two years with ear problems that led to scratching, often until her skin was raw. Vet-recommended remedies had been temporary, quick-fixes, Sara says, but the discomfort always returned with a vengeance. For the pet trials, Sara gave Roxy two tabs of the product a day for two months, noting this is the only supplement she was getting. Sara says Roxy’s problem with her ears definitely improved, the hair as grown back on her head and ears, and the ear problem has not recurred, adding that Roxy is happier and engaging, more playful.

The National Health Institute lists seventy-four treatable diseases using ASCs in therapy – an invasive and costly procedure of removing the stem cells from one’s bone marrow (or a donor’s bone marrow) and re-injecting these same cells into an area undergoing treatment. For example, this procedure is sometimes done before a cancer patient undergoes radiation. Healthy stem cells from the bone marrow are removed and stored, only to be re-inserted after radiation into the area of the body in need of repair. This is a complex and expensive procedure, not accessible to the average person. However, there is now a way that every single person, no matter what their health condition, can have access to the benefits of naturally supporting their body’s innate ability to repair every organ and tissue using stem cell nutrition.

David A. Prentice, Ph.D. – “Within just a few years, the possibility that the human body contains cells that can repair and regenerate damaged and diseased tissue has gone from an unlikely proposition to a virtual certainty. Adult stem cells have been isolated from numerous adult tissues, umbilical cord, and other non-embryonic sources, and have demonstrated a surprising ability for transformation into other tissue and cell types and for repair of damaged tissues.

A new U.S. study involving mice suggests the brain’s own stem cells may have the ability to restore memory after an injury. These neural stem cells work by protecting existing cells and promoting neuronal connections. In their experiments, a team at the University of California, Irvine,were able to bring the rodents’ memory back to healthy levels up to three months after treatment. The finding could open new doors for treatment of brain injury, stroke and dementia, experts say.

“This is one of the first reports that you can take a stem cell transplantation approach and restore memory,” said lead researcher Mathew Blurton-Jones, a post doctorate fellow at the university. “There is a lot of awareness that stem cells might be useful in treating diseases that cause loss of motor function, but this study shows that they might benefit memory in stroke or traumatic brain injury, and potentially Alzheimer’s disease.”

In the study, published in the Oct. 31 issue of the Journal of Neuroscience, Blurton-Jones and his colleagues used genetically engineered mice that naturally develop brain lesions. The researchers destroyed cells in a brain area called the hippocampus. These cells are known to be vital to memory formation and it is in this region that neurons often die after injury, the researchers explained. To test the mice’s memory, Blurton-Jones’s group conducted place and object recognition tests with both healthy mice and brain-injured mice.

Healthy mice remembered their surroundings about 70 percent of the time, while brain-injured mice remembered it only 40 percent of the time. For objects, healthy mice recalled objects about 80 percent of the time, but injured mice remembered them only 65 percent of the time. The researchers then injected each mouse with about 200,000 neural stem cells. They found that mice with brain injuries that received the stem cells now remembered their surroundings about 70 percent of the time — the same as healthy mice. However, mice that didn’t receive stem cells still had memory deficits.

The researchers also found that in healthy mice injected with stem cells, the stem cells traveled throughout the brain. In contrast, stem cells given to injured mice lingered in the hippocampus. Only about 4 percent of those stem cells became neurons, indicating that the stem cells were repairing existing cells to improve memory, rather than replacing the dead brain cells, Blurton-Jones’s team noted. The researchers are presently doing another study with mice stricken with Alzheimer’s. “The initial results are promising,” Blurton-Jones said. “This has a huge potential, but we have to be cautious about not rushing into the clinic too early.”

One expert is optimistic about the findings. “Putting in these stem cells could eventually help in age-related memory decline,” said Dr. Paul R. Sanberg, director of the Center of Excellence for Aging and Brain Repair at the University of South Florida College of Medicine. “There is clearly a therapeutic potential to this.” Sanberg noted that for the process to work with Alzheimer’s it has to work with older brains. “There is clearly therapeutic potential in humans, but there are a lot of hurdles to overcome,” he said. “This is another demonstration of the potential for neural stem cells in brain disorders.”.

Dr. Nancy White Ph.D.- ” I’ve always been interested in health generally and in particular the brain, focusing on the balance of neurotransmitters. I often do quantitative EEG’s for assessment of my patients. I’m impressed with the concept of a natural product like stem cell nutrition that could help release adult stem cells from the bone mass where the body would have no objection and no rejection. I’ve tried stem cell nutrition for general health anti-aging. After taking it for a time, I fell more agile and my joints are far more flexible. I was astounded while doing yoga that I was suddenly able to bend over and touch my forehead to my knees. I haven’t been able to do that comfortably in probably twenty years. I noticed how much better my balance has become. I believe stem cell nutrition is responsible for these effects, because I certainly haven’t been trained extensively in yoga. Also since taking stem cell nutrition, I feel better and my skin is more moist and has a finer texture.

A bald friend of mine, who is also taking the stem cell nutrition, had several small cancers on top of his head. His doctor had removed one from his arm already, and his dermatologist set a date to remove those from his scalp. Before the appointment, my friend was shaving one morning and, looking in the mirror, saw that the cancers were all gone. They had disappeared within a few weeks of starting the stem cell nutrition and his skin is better overall. Also, his knee, which he’d strained playing tennis, was like new. Stem cell nutrition seems to go where the body’s priority is. You never know what the affect is going to be, but you notice something is changing. Another friend of mine seems to be dropping years. Her skin looks smoother and her face younger. After about six weeks on the stem cell nutrition, she looks like she’s ten years younger. A woman who gives her regular facials asked what she was doing, because her skin looked so much different. Stem cell nutrition is remarkable and could help anybody. Everybody should try it, because it’s natural and there are no risks. As we grow older in years, we still can have good health. That’s the ideal. Even if you don’t currently have a problem, stem cell nutrition is a preventative.”Dr. White holds a Ph. D. in Clinical Psychology, an MA in Behavioral Science, and a B.F.A. in Fine Arts, Magna Cum Laude. In addition, she is licensed in the State of Texas as a Psychologist , a Marriage and Family Therapist and as a Chemical Dependency Counselor.

Fernando Aguila, M.D. – “Due to a heavy patient load, I have recently found that I tire more easily, my legs are cramping, and by the time I get home, even my shoulders and rib cage hurt. I knew I had to find a way to increase my stamina, energy and vitality. A friend gave me information about stem cell nutrition and how it promotes the release of stem cells in the body. One of the components apparently promotes the migration of the stem cells to tissues or organs where regeneration and repair is needed most. My attention was drawn to the fact that it can increase energy, vitality, wellness, concentration, and much more. It sounded just like what I needed. Since then, I’ve heard reports of people experiencing excellent results in a number of different areas in their health. The improvements sounded dramatic. Because of all of their testimonies, I was willing to believe it could promote wellness in the human body.

I tried stem cell nutrition myself. After a day, of hard work, I realized I wasn’t tired at all, my legs were not aching, and I didn’t have any shoulder pain. I decided the stem cell nutrition must be working. I continued to take it, and was able to work so efficiently and steadily that one surgeon commented that I was moving like a ball of fire. Stem cell nutrition gives me support physically and mentally. I look forward to seeing what the major medical journals have to say about the studies being done with this new approach to wellness.”Fernando Aguila, M.D., graduated from the University of Santa Thomas in Manila , Philippines. He finished his internship at Cambridge City Hospital, Cambridge, MA and completed his residency at the New England Medical Center in Boston, MA. He obtained a fellowship in OB-GYN anesthesia at the Brigham and Women’s Hospital in Boston and a fellowship in cardio-thoracic anesthesia at the Cleveland Clinic Foundation in Cleveland, OH.

Christian Drapeau is America’s best known advocate for Adult Stem Cell science health applications and the founder of the field of Stem Cell Nutrition. He holds a BS in Neurophysiology from McGill University and a Master of Science in Neurology and Neurosurgery from the Montreal Neurological Institute.

One particular stem cell enhancers that was studied was found to contain a polysaccharide fraction that was shown to stimulate the migration of Natural Killer (NK) cells out of the blood into tissues. The same polysaccharide fraction was also shown to strongly stimulate the activation of NK cells. NK cells play the very important role in the body of identifying aberrant or defective cells and eliminating them. NK cells are especially known for their ability to detect and destroy virally infected cells and cells undergoing uncontrolled cellular division. The same polysaccharide fraction was also shown to stimulate macrophage activity. Macrophages constitute the front line of the immune system. They first detect an infection or the presence of bacteria or virally infected cells, and they then call for a full immune response. Adult Stem Cell Nutritional Enhancer also contains a significant concentration of chlorophyll and phycocyanin, the blue pigment in AFA. Phycocyanin has strong anti-inflammatory properties and therefore can assist the immune system.

The release of stem cells from the bone marrow and their migration to tissues is a natural process that happens everyday.Stem cell enhancers simply support that natural process and tips the balance toward health everyday. It does not do anything that the body does not already do everyday. So far, no instances of cancer or any similar problem have ever been observed when using in vivo natural release of stem cells from the bone marrow.

Each day, stem cells in the bone marrow evolve to produce red blood cells, white blood cells, and platelets. These mature cells are then released into the bloodstream where they perform their vital life-supporting functions. When bone marrow stem cell activity is interfered with, diseases such as anemia (red blood cell deficit), neutropenia (specialized white blood cell deficit), or thrombocytopenia (platelet deficit) are often diagnosed. Any one of these conditions can cause death if not corrected.

Scientists have long known that folic acid, vitamin B12, and iron are required for bone marrow stem cells to differentiate into mature red blood cells. Vitamin D has been shown to be crucial in the formation of immune cells, whereas carnosine has demonstrated a remarkable ability to rejuvenate cells approaching senescence and extend cellular life span.

Other studies of foods such as blueberries show this fruit can prevent and even reverse cell functions that decline as a result of normal aging. Blueberry extract has been shown to increase neurogenesis in the aged rat brain. Green tea compounds have been shown to inhibit the growth of tumor cells, while possibly providing protection against normal cellular aging.

Based on these findings, scientists are now speculating that certain nutrients could play important roles in maintaining the healthy renewal of replacement stem cells in the brain, blood, and other tissues. It may be possible, according to these scientists, to use certain nutrient combinations in the treatment of conditions that warrant stem cell replacement

These studies demonstrate for the first time that various natural compounds can promote the proliferation of human bone marrow cells and human stem cells. While these studies were done in vitro, they provide evidence that readily available nutrients may confer a protective effect against today’s epidemic of age-related bone marrow degeneration.

Dr. Robert Sampson, MD on stem cell nutrition – “… we have a product that has been shown and demonstrated in the patent to increase the level of adult circulating stem cells by up to 30%. It seems to me we’re having a great opportunity here to optimize the body’s natural ability to create health.”Recent scientific developments have revealed that stem cells derived from the bone marrow, travel throughout the body, and act to support optimal organ and tissue function. Stem cell enhancers supports the natural role of adult stem cells. Stem cell enhancer are typically derived from certain edible algae that grows in fresh water.

The possibility that a decline in the numbers or plasticity of stem cell populations contributes to aging and age-related disease is suggested by recent findings. The remarkable plasticity of stem cells suggests that endogenous or transplanted stem cells can be tweaked’ in ways that will allow them to replace lost or dysfunctional cell populations in diseases ranging from neurodegenerative and hematopoietic disorders to diabetes and cardiovascular disease.

As you age, the number and quality of stem cells that circulate in your body gradually decrease, leaving your body more susceptible to injury and other age-related health challenges. Just as antioxidants are important to protect your cells from free radical damage, stem cell nutrition is equally important to support your stem cells in maintaining proper organ and tissue functioning in your body.

A fundamental breakthrough in our understanding of nervous system development was the identification of multipotent neural stem cells (neurospheres) about ten years ago. Dr. Weiss and colleagues showed that EGF (epidermal growth factor) dependent stem cells could be harvested from different brain regions at different developmental stages and that these could be maintained over multiple passages in vitro. This initial finding has lead to an explosion of research on stem cells, their role in normal development and their potential therapeutic uses. Many investigators have entered this field and the progress made has been astounding.

How does an increase in the number of circulating stem cells lead to optimal health?Circulating stem cells can reach various organs and become cells of that organ, helping such organ regain and maintain optimal health. Recent studies have suggested that the number of circulating stem cells is a key factor; the higher the number of circulating stem cells the greater is the ability of the body at healing itself. Scientific interest in adult stem cells has centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. Adult stem cells are already being used clinically to treat many diseases. These include as reparative treatments with various cancers, autoimmune disease such as multiple sclerosis, lupus and arthritis, anemias including sickle cells anemia and immunodeficiencies. Adult stem cells are also being used to treat patients by formation of cartilage, growing new corneas to restore sight to blind patients, treatments for stroke, and several groups are using adult stem cells to repair damage after heart attacks. Early clinical trials have shown initial success in patient treatments for Parkinsons disease and spinal cord injury. The first FDA approved trial to treat juvenile diabetes in human patients is ready to begin at Harvard Medical School, using adult stem cells. An advantage of using adult stem cells is that in most cases, the patients own stem cells can be used for the treatment, circumventing the problems of immune rejection, and without tumor formation.

Why do we hear much in the news about embryonic stem cells and very little about adult stem cells?The first human embryonic stem cells were grown in vitro, in a petri dish, in the mid 1990s. Rapidly, scientists were successful at growing them for many generations and to trigger their differentiation into virtually any kind of cells, i.e. brain cells, heart cells, liver cells, bone cells, pancreatic cells, etc. When scientists tried growing adult stem cells, the endeavor was met with less success, as adult stem cells were difficult to grow in vitro for more than a few generations. This led to the idea that embryonic stem cells have more potential than adult stem cells. In addition, the ethical concerns linked to the use of embryonic stem cells have led to a disproportionate representation of embryonic stem cells in the media. But recent developments over the past 2-3 years have established that adult stem cells have capabilities comparable to embryonic stem cells in the human body, not in the test tube. Many studies have indicated that simply releasing stem cells from the bone marrow can help support the body’s natural process for renewal of tissues and organs.

The bone marrow constantly produces stem cells for the entire life of an individual. Stem cells released by the bone marrow are responsible for the constant renewal of red blood cells and lymphocytes (immune cells). A 25-30% increase in the number of circulating stem cells is well within physiological range and does not constitute stress on the bone marrow environment. The amount of active bone marrow amounts to about 2,600 g (5.7 lbs), with about 1.5 trillion marrow cells. Stem cells that do not reach any tissue or become blood cells return to the bone marrow.

Effectiveness of stem cell “enhancers” was demonstrated in a triple-blind study. Volunteers rested for one hour before establishing baseline levels. After the first blood samples, volunteers were given stem cell “enhancers”or placebo. Thereafter, blood samples were taken at 30, 60 and 120 minutes after taking the consumables. The number of circulating stem cells was quantified by analyzing the blood samples using Fluorescence-Activated Cell Sorting (FACS). Consumption of stem cell “enhancers” triggered a significant 25-30% increase in the number of circulating stem cells.

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Can Stem Cell Plant-Based be an Alternative to Embryonic …

Why Stem Cell Therapy for Pets? | MediVet Biologics

What happens to my pet when they come in for stem cell therapy?

First, your vet will put your pet under general anesthetic. Then, he/she will make a small incision and collect 2-4 tablespoons of fat (either in the belly or behind the shoulder blades). MediVet provides on-site training for each clinic that brings on Stem Cell treatments; the process ensures your pets cells will be isolated and activated in a proper manner.

The surgical time requiring anesthesia is typically less than 30 minutes. The cells are isolated, activated and re-administered on site so that your animal can go home same day.

What is the recovery period, and how long does it take to see results?

We recommend that the patient be limited to activity within the first 10 days. It is likely your pet will be feeling good and want to exert themselves, however we recommend limiting physical activity so the cells have the ability to work to repair injuries. Improvements are typically seen within the first two weeks and continue improve over the next few months. Veterinarians report responses from initial treatments lasting 18-24 months. Rehabilitation Schedule.

MediVets patented stem cell procedure allows your vet to isolate stem cells from your animals own fat tissue, activate them, and reintroduce them directly into the damaged areas all in one visit. The goal of this revolutionary procedure is to provide a potent anti-inflammatory effect promoting cartilage and other tissue regeneration ultimately creating a healthier environment for the affected area. Most importantly, its an all-natural approach to healing without the adverse side effects. One example, in the case of arthritis, stem cells can become new cartilage cells, thus reducing pain and increasing mobility.

How long does a treatment last? What happens if my pet starts having trouble again?

We typically see about 18-24 months of relief after the initial treatment and even longer when treatment is sought at earlier stages. Most pet owners chose to bank cells, so re-treatment is easy and cost effective. MediVet has banking facilities in Kentucky, Australia and Europe. If symptoms return, your vet merely requests a dose of cells from the bank, and injects them. No surgery is necessary.

How long has this been available?

Stem cell therapy for animals has been commercially available since 2004. MediVet pioneered in-clinic treatment options around 2010 and has now successfully treated thousands of animals globally.

What is so great about Stem Cell Therapy?

Stem cells treat the source of the problem by becoming new tissue replacing damaged tissue. Other treatments, such as NSAIDs, merely attempt to reduce symptoms. The treatment is very low risk, because it uses the animals own stem cells. With MediVets technology in a recent study conducted by four independent Veterinarians over 95% of animals treated show improvement. For pet owners, there are two main advantages to MediVet.

155 Canine Study

What conditions do you treat?

Our typical patient has osteoarthritis (hip dysplasia, degenerative joint disease, calcifications, common degeneration and inflammation), soft tissue injuries (cruciate injuries, tears, ruptures, inflammation), or needs accelerated healing of fractures. We know a lot about these conditions, and over 95% of these patients get better, with MediVets Stem Cell Therapy.We also treat other cases under compassionate use. We know less about these conditions, but are seeing some exciting results. Some of those conditions are: degenerative myelopathy, feline gingivitis, end-stage renal disease, liver and kidney failure, allergy, auto-immune, inflammatory bowel disease, pulmonary fibrosis, IMHA, atopy, and spine trauma. Please talk to your vet if you have questions about any of these conditions or would like to submit your animal for a compassionate use trial.

Is it safe?

Yes, this procedure is very safe. The biggest risk as in any surgical procedure is using anesthetic, to remove the fat tissue. On a typical dog, Veterinarians report this procedure is easier than a spay. The fat is collected in about 20 minutes by your vet. Processing the sample is done carefully by a highly trained Vet tech carefully trained by MediVet. In the thousands of animals treated, we have not observed any significant negative side-effects from MediVets stem cell therapy.

KSU Study Double blind placebo controlled study of Osteoarthritis model

UK Study The only validated independent comparative analysis done of MediVets Stem Cell Therapy Procedure (Stromal Vascular Fraction (SVF)

KSU Study Double blind controlled study of Atopic Dermatitis using MediVets Stem Cell Therapy Procedure (Stromal Vascular Fraction therapy (21 dogs)

Read more from the original source:
Why Stem Cell Therapy for Pets? | MediVet Biologics

Concerns over paraplegic dog’s treatment – INFORUM

Tommy, our beloved 8-year-old border collie mix, was diagnosed by MRI with an inoperable tumor on his spinal cord. We had difficulty diagnosing what appeared to be a weak leg, and he began to cry out occasionally as he climbed stairs. We escalated, and our vet referred us to an MRI immediately.

After the diagnosis, the vet specialist said that Tommy was quite stoic because he did not cry out more often, given the location of the tumor. We knew he was not himself, but what we did not know was the level of pain that he lived with that last month of his life.

I question the motivation of these people: How on Earth (in their own words) “during four weeks of screaming in pain” did they not decide that perhaps it was time to let Chuckie go? Who knows what pain he endures now? I was saddened to see that their own motivations have overtaken their empathy for what might be in the best interest of Chuckie.M.J., Manchester, Mo.

Dear Dr. Fox: I was dismayed by the excessive treatment the letter-writer has gotten and is getting for a paraplegic dog. I love animals, have taken good care of my pets and have volunteered and donated to the Missouri Humane Society, so it isn’t that I’m anti-animal, but I think what the writer has done for this one dog is too much.

Just think of the hundreds and hundreds of dogs in shelters and the care some of the healthier ones could get if the writer stopped at sensible treatment for that one dog. Actually, that dog is getting better and more extensive care than some children. Enough is enough in trying to help a pet.R.B., Kirkwood, Mo.

Dear M.J. and R.B.: The money that caring people sometimes put out for their beloved animal companions, especially with advances in cancer treatments and stem cell therapies, can be very considerable. Are they being selfish? What then of their love and concern?

Some do choose instead to opt for euthanasia, especially when there is a low chance of recovery, and give a large donation in their animal’s name to their local animal shelter or rescue organization.

We cannot compare the quality of medical care and what might be spent on a child in a poor village with a toy poodle in New York City suffering from comparable conditions, nor their chances of recovery. Such situational ethics are confounded by other social and family priorities, availability of services and where there is choice, just how much one feels like spending and can afford in the hope that the loved one will recover. It is a tragedy of the times that here in America, families can be bankrupted by the medical bills of one member under cancer treatment.

Just as we see with people, dogs do vary greatly in their pain tolerance; some are more stoic than others, who may border on hysteria because of fear as well as pain. This is where the experienced clinical eye of the veterinarian is invaluable to determine the best course of treatment and the animal patient’s quality of life and chances of total or partial recovery.

Regardless of costs and affordability and the fact that some animal caregivers may seek to extend an animal’s life for various personal reasons rather than for the animal’s own sake, all involved have a duty to make the animal patient as comfortable as possible and give the animal a chance where there is a strong will to live.

Being nursed at home or setting up in-home palliative care with a visiting veterinarian may be preferable to long-term hospitalization where recovery may be protracted or arrested by separation anxiety and loss of the will to live.

Send all mail to animaldocfox@gmail.com or to Dr. Michael Fox in care of Universal Uclick, 1130 Walnut St., Kansas City, MO 64106. The volume of mail received prohibits personal replies, but questions and comments of general interest will be discussed in future columns. Visit Dr. Fox’s website at http://www.drfoxvet.net.

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Concerns over paraplegic dog’s treatment – INFORUM

Animal Stem Cell Therapy Market: Outlook Continues to Remain Positive by 2017 2025 – LANews By Abhishek Budholiya (press release) (blog)

Animal stem cell therapy is a usage of animals stem cell to treat a disease or disorder. The ability of stem cell is to divide and differentiate into a cell with specialized function useful for repairing body tissues damaged by injury or disease. The animal stem cell therapy process involve three steps which include collection of stem cell sample from animals and preparing the sample to concentrate the stem cells. Finally, the therapy includes transferring the stem cells into the injured site for treatment. Animal stem cell therapy increases the expectancy of life in animals with no side effects. It is available for the treatment of arthritis, degenerative joint disorders, tendon, and ligaments injuries in animals. Stem cell therapy is most often used to treat dogs, cats, and horses. But recent developments made it possible to use animal stem cell therapy in tiger, pig, etc. Present animal stem cell therapy is studied in treatments of the inflammatory bowel, kidney, liver, heart and immune-mediated diseases respectively.

Animal Stem Cell Therapy Market Drivers and Restraints,Segmentation,Region-wise Overview and Key Participants:

Increasing prevalence of disease in animals with growing population and to increase the animals quality of life, the companies focus shifting towards animal stem cell therapies. Along with increasing government funding for the protection of animals and fast approvals of FDA contributing towards the rapid growth of the animal stem cell therapy. The research in animal stem cells offers great promise for understanding underlying mechanisms of animal development; it gives great opportunities to treat a broad range of diseases and conditions in animals. Animal stem cell therapy is increasingly recognized as critical translational models of human disease for treatment. All these factors act as drivers for the robust growth of the animal stem cell therapy market.

There are little evidence-based preclinical animal studies acts as restraint in the animal stem cell therapy market. The evidence-based clinical trials of animal stem cell therapy provide tremendous opportunities for the efficient advancement of other species.

Segmentation based on Applications: Dog, Cat, Horse, Others;Segmentation based on End-user: Veterinary hospitals, Veterinary Clinics, Research organizations.

Studies in the animal stem cell therapy continue at a breathtaking pace due to increasing demand and treatment cost covered in reimbursements. And animal stem cell therapy is more effective than traditional treatment available in the market which is boosting the companies to increase the spending in the R&D for innovative methods. Because of the novelty and complexity of animal stem cell therapy, FDA encourages individuals, universities and drug companies for further innovations. The future expected with double CAGR during the forecasted period.

Regarding geographies, North America is dominating the global animal stem cell therapy market due to the increased incidence rate and awareness about the therapy. U.S represents the largest market share in the North America due to the increasing demand for the therapy. Europe and Asia-Pacific are showing a significant growth rate during the forecasted period due to the growing adoption of the animal stem cell therapy. The animal stem cell therapy market in underdeveloped countries is slow when compared to the developed countries.

The key participants in the animal stem cell therapy market are Magellan Stem Cells, ANIMAL CELL THERAPIES, Abbott Animal Hospital, VETSTEM BIOPHARMA, Veterinary Hospital and Clinic Frisco, CO, etc. The companies are entering into the collaboration and partnership to keep up the pace of the innovations.

A sample of this report is available upon request @https://www.persistencemarketresearch.com/samples/14941

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Animal Stem Cell Therapy Market: Outlook Continues to Remain Positive by 2017 2025 – LANews By Abhishek Budholiya (press release) (blog)

Spike in drugs found at Wandsworth Prison after sniffer dog handler … – Evening Standard

Britains largest prison is failing to stem the flow of drugs into cells after its sniffer dog had time off and amid a shortage of CCTV operators, its monitors said today.

The Independent Monitoring Board for Wandsworth Prison said illicit substances were fuelling violence as it issued a highly critical report on conditions.

In one month, dog searches were conducted on only 10 out of 31 days.

It said: It had been intended that Wandsworth should be a hub for the new regional dog team but no new staff were appointed and there was no cover made available when the one dog handler went on training or leave.

As a result dog searches had decreased.

The security risk was worsened by the lack of operational CCTV to monitor visitors.

Drug failure: Wandsworth prison (Picture: Nigel Howard)

The board warned that Wandsworth had once again been unable to provide a consistently safe, decent and humane environment for its 1,600 prisoners over the past year.

It blamed the failure on severe staff shortages which were undermining the efforts of the prisons strong management team and hard-pressed officers and affecting almost every aspect of prison life.

The resulting problems included prisoners being locked in their cells for excessive periods. This was causing boredom and frustration and contributing to high levels of violence.

Staff shortages were also preventing education and training which was vital to the process of rehabilitating offenders and preventing recidivism.

On the drugs problem, the board said there were almost daily drone deliveries last summer, helped by the large number of smashed cell windows, but that airborne smuggling had decreased sharply after a police car chase of a suspected drone operator resulted in a fatality.

Other measures had also helped and there had been no known drone deliveries since last September.

Other forms of smuggling continued. Several staff had been excluded after being subjected to X-ray and dog searches. But the amount of contraband being brought in by visitors remained relatively high because of the lack of staff to monitor CCTV or conduct sniffer dog checks.

The boards report also disclosed that about 40 per cent of Wandsworths inmates are foreign nationals, with 112 Poles forming the largest contingent.

The Ministry of Justice said recruitment of dog handlers was under way at a regional level and that posts at Wandsworth are expected to be filled in the near future.

It added: Wandsworth has already taken action to address a number of concerns raised in the report, including a targeted, local recruitment campaign which has already begun to boost the number of prison officers in post.

The prison has also put in place new measures to tackle the supply and use of illegal contraband. This includes the recruitment of new dog handler posts to step up drug detection.

Excerpt from:
Spike in drugs found at Wandsworth Prison after sniffer dog handler … – Evening Standard

Fetal membranes may help transform regenerative medicine – Medical Xpress

A new review looks at the potential of fetal membranes, which make up the amniotic sac surrounding the fetus during pregnancy, for regenerative medicine.

Fetal membranes have been used as biological bandages for skin grafts as well as for serious burns. They may also have numerous other applications because they contain a variety of stem cells, which might be used to treat cardiovascular and neurological diseases, diabetes, and other medical conditions.

“The fetal membranes have been used successfully in medical applications for over a century, but we continue to discover new properties of these membranes,” said Dr. Rebecca Lim, author of the STEM CELLS Translational Medicine review. “The stem cell populations arising from the fetal membranes are plentiful and diverse, while the membrane itself serves as a unique biocompatible scaffold for bioengineering applications.”

Explore further: Stem cell research could prevent premature births

More information: Rebecca Lim. Concise Review: Fetal Membranes in Regenerative Medicine: New Tricks from an Old Dog?, STEM CELLS Translational Medicine (2017). DOI: 10.1002/sctm.16-0447

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Fetal membranes may help transform regenerative medicine – Medical Xpress

Stem cell treatment for children with spina bifida helps puppies first – University of California

A pair of English bulldog puppies are the first patients to be successfully treated with a unique therapy a combination of surgery and stem cells developed at the University of California, Davis, to help preserve lower-limb function in children with spina bifida.

Because dogs with the birth defect frequently have little control of their hindquarters, they also have little hope for a future. They are typically euthanized as puppies.

At their postsurgery re-check at 4 months old, however, the siblings, named Darla and Spanky, showed off their abilities to walk, run and play to their doctor,veterinary neurosurgeon Beverly Sturges.

The initial results of the surgery are promising, as far as hind limb control, said Sturges. Both dogs seemed to have improved range of motion and control of their limbs.

The dogs have since been adopted, and continue to do well at their home in New Mexico.

Spina bifida occurs when spinal tissue improperly fuses in utero, causing a range of cognitive, mobility, urinary and bowel disabilities in about 1,500 to 2,000 children born in the U.S. each year. The dogs procedure, which involved surgical techniques developed byfetal surgeon Diana Farmerof UC Davis Health together with a cellular treatment developed by stem cell scientistsAijun WangandDori Borjesson, director of the universitysVeterinary Institute for Regenerative Cures, represents a major step toward curing spina bifida for both humans and dogs.

Farmer pioneered the use of surgery prior to birth to improve brain development in children with spina bifida. She later showed that prenatal surgery combined with human placenta-derived mesenchymal stromal cells (PMSCs), held in place with a cellular scaffold, helped research lambs born with the disorder walk without noticeable disability.

Sturges wanted to find out if the surgery-plus-stem-cell approach could give dogs closer-to-normal lives along with better chances of survival and adoption. At 10-weeks old, Darla and Spanky were transported from Southern California Bulldog Rescue to the UC Davis veterinary hospital, where they were the first dogs to receive the treatment, this time using canine instead of human PMSCs.

Another distinction for Darla and Spanky is that their treatment occurred after birth, since prenatal diagnosis of spina bifida is not performed on dogs, Sturges explained. The disorder becomes apparent between 1 and 2 weeks of age, when puppies show hind-end weakness, poor muscle tone, incoordination and abnormal use of their tails.

UC Davis is the only place where this type of cross-disciplinary, transformational medicine could happen, according to Farmer.

Its rare to have a combination of excellent medical and veterinary schools and strong commitment to advancing stem cell science at one institution, she said.

UC Davis is also home to the One Healthinitiative aimed at finding novel treatmentslike thesefor diseases that affect both humans and animals.

Ive often said that I have the greatest job on the planet, because I get to help kids, Farmer said. Now my job is even better, because I get to help puppies too.

With additional evaluation and U.S. Food and Drug Administration approval, Farmer and Wang hope to test the therapy in human clinical trials. Sturges and Borjesson hope to do the same with a canine clinical trial. They hope the outcomes of their work help eradicate spina bifida in dogs and humans.

In the meantime, the team wants dog breeders to send more puppies with spina bifida to UC Davis for treatment and refinements that help the researchers fix an additional hallmark of spina bifida incontinence. While Darla and Spanky are very mobile and doing well on their feet, they still require diapers.

Further analysis of their progress will determine if the surgery improves their incontinence conditions, Sturges said.

Funding for this project was provided by the Veterinary Institute for Regenerative Cures (VIRC) at the UC Davis School of Veterinary Medicine, and the Surgical Bioengineering Lab at the UC Davis School of Medicine. Private donations to the veterinary school for stem cell research also contributed to this procedure. Farmer and Wangs spina bifida research is supported by funding from the National Institutes of Health, the California Institute for Regenerative Medicine, Shriners Hospitals for Children and the March of Dimes Foundation.

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Stem cell treatment for children with spina bifida helps puppies first – University of California

Stem Cell Treatment for Children With Spina Bifida Helps Dogs First … – UC Davis

A pair of English bulldog puppies are the first patients to be successfully treated with a unique therapy a combination of surgery and stem cells developed at the University of California, Davis, to help preserve lower-limb function in children with spina bifida.

(Editorsnote: Photos and b-roll available.)

Because dogs with the birth defect frequently have little control of their hindquarters, they also have little hope for a future. They are typically euthanized as puppies.

At their postsurgery re-check at 4 months old, however, the siblings, named Darla and Spanky, showed off their abilities to walk, run and play to their doctor, veterinary neurosurgeon Beverly Sturges.

The initial results of the surgery are promising, as far as hind limb control, said Sturges. Both dogs seemed to have improved range of motion and control of their limbs.

The dogs have since been adopted, and continue to do well at their home in New Mexico.

Spina bifida occurs when spinal tissue improperly fuses in utero, causing a range of cognitive, mobility, urinary and bowel disabilities in about 1,500 to 2,000 children born in the U.S. each year. The dogs procedure, which involved surgical techniques developed by fetal surgeon Diana Farmer of UC Davis Health together with a cellular treatment developed by stem cell scientists Aijun Wang and Dori Borjesson, director of the universitys Veterinary Institute for Regenerative Cures, represents a major step toward curing spina bifida for both humans and dogs.

Farmer pioneered the use of surgery prior to birth to improve brain development in children with spina bifida. She later showed that prenatal surgery combined with human placenta-derived mesenchymal stromal cells (PMSCs), held in place with a cellular scaffold, helped research lambs born with the disorder walk without noticeable disability.

Sturges wanted to find out if the surgery-plus-stem-cell approach could give dogs closer-to-normal lives along with better chances of survival and adoption. At 10-weeks old, Darla and Spanky were transported from Southern California Bulldog Rescue to the UC Davis veterinary hospital, where they were the first dogs to receive the treatment, this time using canine instead of human PMSCs.

Another distinction for Darla and Spanky is that their treatment occurred after birth, since prenatal diagnosis of spina bifida is not performed on dogs, Sturges explained. The disorder becomes apparent between 1 and 2 weeks of age, when puppies show hind-end weakness, poor muscle tone, incoordination and abnormal use of their tails.

UC Davis is the only place where this type of cross-disciplinary, transformational medicine could happen, according to Farmer.

Its rare to have a combination of excellent medical and veterinary schools and strong commitment to advancing stem cell science at one institution, she said.

UC Davis is also home to the One Healthinitiative aimed at finding novel treatments like these for diseases that affect both humans and animals.

Ive often said that I have the greatest job on the planet, because I get to help kids, Farmer said. Now my job is even better, because I get to help puppies too.

With additional evaluation and U.S. Food and Drug Administration approval, Farmer and Wang hope to test the therapy in human clinical trials. Sturges and Borjesson hope to do the same with a canine clinical trial. They hope the outcomes of their work help eradicate spina bifida in dogs and humans.

In the meantime, the team wants dog breeders to send more puppies with spina bifida to UC Davis for treatment and refinements that help the researchers fix an additional hallmark of spina bifida incontinence. While Darla and Spanky are very mobile and doing well on their feet, they still require diapers.

Further analysis of their progress will determine if the surgery improves their incontinence conditions, Sturges said.

Funding for this project was provided by the Veterinary Institute for Regenerative Cures (VIRC) at the UC Davis School of Veterinary Medicine, and the Surgical Bioengineering Lab at the UC Davis School of Medicine. Private donations to the veterinary school for stem cell research also contributed to this procedure. Farmer and Wangs spina bifida research is supported by funding from the National Institutes of Health, the California Institute for Regenerative Medicine, Shriners Hospitals for Children and the March of Dimes Foundation.

Excerpt from:
Stem Cell Treatment for Children With Spina Bifida Helps Dogs First … – UC Davis

Terre Haute animal hospital in stem cell study for dogs – WISH-TV

Deana ReecePublished: August 23, 2017, 7:22 pmUpdated: August 23, 2017, 9:34 pm

TERRE HAUTE, Ind. (WTWO) Maggie Mae and her owner, Robert Howrey, came from Paris, Illinois, for a check-up at the Wabash Valley Animal Hospital in Terre Haute.

She doesnt act like it, but Maggie Mae is a senior citizen and she has problems with her joints.

Arthritis is a common condition in older dogs and we like to help them out, said Dr. Andrew Pickering, a local veterinarian.

A California company called Animal Cell Therapies has enlisted U.S. veterinarians to participate in a study of using stem cells for dogs with arthritis. Some of the canines in the study receive an injection of stem cells, others get just a saline solution.

Pickering doesnt know which injections Maggie Mae is getting, but she no longer limps. Hes encouraged by the results.

Were hoping this particular type of treatment will cure the condition for a long period of time so we dont have to keep giving the dog medication all the time, Pickering said.

Howrey said its almost like having a new dog.

Its been about six weeks, so now shes back doing normal activities, she runs, she chases squirrels.

The research will continue for several more months. The local clinic is looking for owners who would like to involve their pets. Study participation is free for dogs that qualify. Plus, even the animals that receive the saline injections can get the stem cell treatment once the study is complete.

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Terre Haute animal hospital in stem cell study for dogs – WISH-TV

Stem cell treatment for children with spina bifida helps dogs first – Phys.Org

An English bulldog undergoes surgery for spina bifida at the UC Davis Veterinary Medical Teaching Hospital. The dog is part of a pair of puppies being treated for spina bifida through a combination of stem cell therapy and surgery, research made possible through collaboration between the UC Davis School of Veterinary Medicine and UC Davis Health. Credit: Gregory Urquiaga/UC Davis

A pair of English bulldog puppies are the first patients to be successfully treated with a unique therapya combination of surgery and stem cellsdeveloped at the University of California, Davis, to help preserve lower-limb function in children with spina bifida.

Because dogs with the birth defect frequently have little control of their hindquarters, they also have little hope for a future. They are typically euthanized as puppies.

At their postsurgery re-check at 4 months old, however, the siblings, named Darla and Spanky, showed off their abilities to walk, run and play to their doctor, veterinary neurosurgeon Beverly Sturges.

“The initial results of the surgery are promising, as far as hind limb control,” said Sturges. “Both dogs seemed to have improved range of motion and control of their limbs.”

The dogs have since been adopted, and continue to do well at their home in New Mexico.

A major step toward curing spina bifida

Spina bifida occurs when spinal tissue improperly fuses in utero, causing a range of cognitive, mobility, urinary and bowel disabilities in about 1,500 to 2,000 children born in the U.S. each year. The dogs’ procedure, which involved surgical techniques developed by fetal surgeon Diana Farmer of UC Davis Health together with a cellular treatment developed by stem cell scientists Aijun Wang and Dori Borjesson, director of the university’s Veterinary Institute for Regenerative Cures, represents a major step toward curing spina bifida for both humans and dogs.

Farmer pioneered the use of surgery prior to birth to improve brain development in children with spina bifida. She later showed that prenatal surgery combined with human placenta-derived mesenchymal stromal cells (PMSCs), held in place with a cellular scaffold, helped research lambs born with the disorder walk without noticeable disability.

Sturges wanted to find out if the surgery-plus-stem-cell approach could give dogs closer-to-normal lives along with better chances of survival and adoption. At 10-weeks old, Darla and Spanky were transported from Southern California Bulldog Rescue to the UC Davis veterinary hospital, where they were the first dogs to receive the treatment, this time using canine instead of human PMSCs.

Another distinction for Darla and Spanky is that their treatment occurred after birth, since prenatal diagnosis of spina bifida is not performed on dogs, Sturges explained. The disorder becomes apparent between 1 and 2 weeks of age, when puppies show hind-end weakness, poor muscle tone, incoordination and abnormal use of their tails.

A unique environment for collaborative research

UC Davis is the only place where this type of cross-disciplinary, transformational medicine could happen, according to Farmer.

“It’s rare to have a combination of excellent medical and veterinary schools and strong commitment to advancing stem cell science at one institution,” she said.

UC Davis is also home to the One Health initiative aimed at finding novel treatments like these for diseases that affect both humans and animals.

“I’ve often said that I have the greatest job on the planet, because I get to help kids,” Farmer said. “Now my job is even better, because I get to help puppies too.”

Hopes for clinical trials in humans and dogs

With additional evaluation and U.S. Food and Drug Administration approval, Farmer and Wang hope to test the therapy in human clinical trials. Sturges and Borjesson hope to do the same with a canine clinical trial. They hope the outcomes of their work help eradicate spina bifida in dogs and humans.

In the meantime, the team wants dog breeders to send more puppies with spina bifida to UC Davis for treatment and refinements that help the researchers fix an additional hallmark of spina bifidaincontinence. While Darla and Spanky are very mobile and doing well on their feet, they still require diapers.

“Further analysis of their progress will determine if the surgery improves their incontinence conditions,” Sturges said.

Explore further: Prenatal stem cell treatment improves mobility issues caused by spina bifida

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Stem cell treatment for children with spina bifida helps dogs first – Phys.Org