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Stem Cell Therapy for Skin Allergy in Dogs and Cats (Pets …

Stem Cell Therapy for skin allergy in Dogs and Cats (before and after), treated by Dr. Kraemeer

Stem Cell Therapy for skin allergies in dogs and cats is now being offered by Dr. Kraemer (DrKraemers.com)Vet4HealthyPet Advanced Medical Care Orange County California Location (Vet4HealthyPet.com). Stem Cell Therapy (regenerative medicine) for dogs and cats has been extensively researched for itspain relief, anti-arthritis, anti-inflammatory and immune modulation properties.

Atopic allergic itch dermatitis is one of the most common skin allergies in dogs and cats. Allergic itch skin dermatitis in pets is usually manifested by the dog or cat itching, biting and causing self-trauma which then leads to hair loss (alopecia) and often secondary bacterial skin infection (pyoderma) and secondary yeast infection (Malassezia).Stem Cell Therapy for skin allergies in Dogs and Cats is showing great therapeutic promise. (StemCell4Pet.com)

Atopic allergic skin dermatitis conjures up thoughts of stressed animals, unhappy owners and frustrated veterinarians. Atopic itch allergic dermatitis in pets is possibly the number one reason for a veterinary office visit for a dog or cat owner. Atopic itch skin dermatitis in pets can be chronic and often requires treatment over an extended period of time, thus a major financial burden to the pet owner.

Stem cells are powerful healing cells that both you and your pet naturally store in a dormant form. Yourdog or cats stem cells are extracted from their fat (adipose tissue) among a mixture of cells termed the Stromal Vascular Fraction (SVF). The SVF is rich in complementary cells and bioactive peptides that contribute to cell proliferation and tissue regeneration.

Dr. Kraemers in house stem cell therapy isolates stem cells from your dog or cats fatty tissue, then activates them (placing the cells into a hyperactive mode) and within hours, reintroduces them to injured and needed body parts.

Stem Cell Therapy for skin allergy in Dogs and Cats before treatment (Severe pododermatitis)

Stem Cell Therapy for skin allergy in Dogs and Cats after treatment by Dr. Kraemer

In contrast to your pets food allergies, avoiding implicated outdoors allergens (grass, weed, trees etc.) and even indoor allergies (mold, dust mites, human dander etc.) is usually difficult to accomplish. Traditionally, most dogs and cats who suffer from allergic itching atopic skin dermatitis are prescribed medication to help modify their symptoms (i.e. anti itching and biting rx). Additional medication can be prescribed to help decrease the secondary infections (bacteria and yeast). Most of the traditional prescribed drugs lack effectiveness and have the potential for accumulative, adverse effects. In addition, over time they become costly and time consuming, thus reducing the owners compliance.Dr. Kraemer has been offering stem cell therapy for dogs and cats for nearly a decade and is a leading provider of a number of non-pharmaceutical/alternative therapeutic modalities. These new age, non-pharmaceutical alternatives such as Laser therapy, Pulse Electromagnetic Therapy (PEMT), and Platelet Rich Plasma (PRP) can all help manage your pets chronic pain andarthritis, as well as assist in treating a wide range of animal diseases and medical conditions. Dr. Kraemer also offers a low cost Cryobanking programs for future stem cell treatments.

Stem Cell Therapy for atopic allergic itch dermatitis in pets is low risk since you are reintroducing your pets own natural repair cells. Dr. Kraemers in-house stem cell therapy service has the advantage over other stem cell providers because the extracting, processing, and treating is all done on location the same day, thus eliminating unnecessary and unwanted cell death due to transportation and time gap between extraction and treatment.

Stem Cell Therapy for atopic itch Skin Allergy in dogs and cats before & after photos treated by Dr. Kraemer

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and Cats Tip #1: Any pet, dog or cat when presented with itching, red irritated skin, patchy hair, bumps, color change and thickness of the effected skin, should suspect allergic atopic itch dermatitis to be the cause.

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and Cats Tip #2:Allergic atopic itch dermatitis in most pets, dogs and cats is localized to the ears, paws, legs, arm pits and abdomen.

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and Cats Tip #3:Common allergens effecting dogs and cats suspected of itch atopic allergic dermatitis include grass, weeds and trees as well as indoor allergens like mold, dust mites and human dandruff.

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and CatsTip #4:For your petswith itching and allergy dermatitis who are under a year old , I recommend an elimination dietary trial to rule out food allergies

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and Cats Tip #5: Platelet Rich Plasma (PRP) allows for an adjunctive autologous value to be added to the stem cell fraction. Platelet Rich Plasma is derived from an autologous whole blood sample from the patient and once processed yields many healing growth factors. PRP can help with survival of the cells upon introducing to the patient, reduce inflammation as well as provide cyto-protective properties when transit is necessary.

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and Cats Tip #6:You should use a flea preventative on your pet especially in geographic location where fleas are common.

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and Cats Tip #7: OTC antihistamines can be used for dog skin allergies like atopic itch dermatitis but its therapeutic effect is questionable.

2 months post stem cell therapy treatment for a bulldog with a severe form of atopic allergic dermatitis

Dr. Kraemers Stem Cell Therapy for skin allergy in Dogs and Cats Tip #8:Treating allergic atopic itch dermatitis should involvebathing your pet with medicated shampoos and conditioners like Dr. Kraemers V4B Itchy Skin Medicated Shampoo as well as frequent use of medicated lotions like Dr. Kraemer V4B waterless lotions line. I usually also recommend topical medicated shampoos like Dr. Kraemers V4B Antiseptic Medicated Shampoo and V4B Yeasty Lotion to help manage the secondary infection.

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Stem Cell Therapy for Skin Allergy in Dogs and Cats (Pets …

Stem Cell Therapy For Dogs – What you should know

Stem cell technology is a new and exciting branch of veterinary medicine. Stem cells are cells that can be safely harvested from a variety of adult animal tissues. Once harvested, the stem cells can be injected and induced to grow into a large number of different cell types.

Stem cell therapy offers the possibility of using these stem cells to grow into replacements for injured or diseased tissues such as bone, cartilage, muscle, nerves, and so on. What makes this such an exciting treatment option is that it allows us to introduce real tissue replacements for damaged tissues, rather than artificial replacement implants. Currently stem cell therapy for dogs is being used with some success to treat bone, joint, and ligament problems.

The technology involves the use of adult stem cells, which can be easily obtained, without any harm to the host animal from which they are taken. A small amount of adipose (fat) tissue is surgically removed from a host animal and a centrifuge is used to separate the stem cells from the fat tissue. The stem cells collected are then injected directly into the injured joint, ligament, or bone where they quickly begin to grow, replacing the damaged tissue with new, healthy tissue.

Stem cell therapy holds immense promise for becoming a viable treatment option for a variety of health issues dog’s face.

At Prestige Animal Hospital, we believe that providing your canine companion with the highest quality medical care means being on the cutting edge of the latest technologies and procedures. This is reflected in every aspect of our approach to stem cell therapy for dogs. Our facilities feature state-of-the-art equipment, and our veterinary team stays up to date on the latest canine stem cell research available.

The ideal candidate for canine stem cell therapy is a dog in otherwise good health that suffers from arthritis or hip dysplasia, and who doesn’t respond well to his or her medication. Or, a dog whose quality of life might further suffer due to invasive surgical procedures. Because canine stem cell therapy uses the patient’s own tissues, a canine must be in overall good health in order for any collected stem cells to be effective.

Canine stem cells are collected through removing either fat cells, or various other applicable tissues from a dog’s body. Within these tissues and cells exist regenerative cells that are known colloquially as dog stem cells. The regenerative cells that are collected do several things:

The best part is that canine stem cells are not synthetic cells being added to a living, biological organism. Rather, canine stem cells are a dog’s own natural healing cells, Because of this, there is much less chance of rejection or adverse interaction, and there are also fewer potential side effects.

Due to the infancy of canine stem cell research and therapies, there is not yet a large body of information about possible adverse side effects. Just like any medical procedure, the risk for adverse side effects from dog stem cell therapy are ever-present. Risks could be associated with the tissue removal procedure, or from a patient’s body rejecting the newly placed cells. Other issues with stem cell therapy for dogs include its effectiveness when used alone. This is because the prescription of traditional medication will accompany stem cell therapy procedures.

Deciding whether or not stem cell therapy for dogs is the right choice for your beloved canine companion is a very personal one. No matter what route you choose to take, we are here to help you make the decision that is in the best interest of your dog, and also that fits your budget and lifestyle.

At this time, most stem cell research for dogs currently focuses on treating bone, joint, and ligament problems, rather than treating more advanced illnesses and diseases. We are extremely confident that the day will come when many canine illnesses and diseases can be treated through advances in canine stem cell research.

One thing seems to be clear, stem cell research for dogs promises to revolutionize the veterinary industry, and is already showing good results with canines that have been treated with dog stem cells to repair joints, bones, or ligaments that have been damaged by injury or disease. We are here to help educate you about the latest canine stem cell research advances, and answer any other questions about dog stem cell therapy you might have.

If you would like to discuss how stem cell therapy can benefit your dog, please contact us to schedule an appointment. Our veterinary team can help you decide whether or not canine stem cell therapy is the right option, including discussing cost and prognosis.

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Stem Cell Therapy For Dogs – What you should know

Stem Cell Research On Dogs – Tufts Your Dog Article

Features June 2013 Issue Looking at ways to improve dogs health and lengthen their lives with stem cell studies.

Just as stem cell research is ushering in a new wave of scientific exploration to heal sick people, studies examining the workings of stem cells are underway for treating sick dogs. To find out just where things are at with stem cell research on dogs behalf, we talked with the Director of the Regenerative Medicine Laboratory at Tufts Cummings School of Veterinary Medicine, Andrew Hoffman, DVM, DVSc, DACVIM.

Andrew Hoffman, DVM, DVSc, DAVIM, Director of Tufts Cummings School’s Regenerative Medicine Laboratory, with a friend.

Your Dog: Is stem cell research for dogs subject to the same ethical considerations as for people? For instance, are dog embryos being created just for their stem cells?

Dr. Hoffman: Actually, very little in the field of stem cell research, either for dogs or for people, has anything to do with growing embryos that are then destroyed.

Your Dog: But isnt that how stem cells are grown?

Dr. Hoffman: For all intents and purposes, no. Its true that a developing embryo, no matter what the species, contains stem cells cells that are undifferentiated and therefore arent yet slated to become specific tissue in the body. But its not true that stem cells can be harvested only from developing embryos and nowhere else.

Your Dog: Where, then, can stem cells be obtained for research, or, when their uses are understood and confirmed, for curing or treating dire diseases?

Dr. Hoffman: Common sources include umbilical tissue, bone marrow, and body fat.

Your Dog: Body fat?

Dr. Hoffman: Yes. A developing embryo has three different types of cells, that is, three major embryonic layers of cells that lodge in different tissue once the animal (or person) is developed. The outer layer of cells is the ectoderm, which later forms skin, nerves, and parts of the eye. In the middle come the mesenchymal cells that layer is called the mesoderm and innermost, the endodermal cells.

The most commonly used stem cells in both animal and human research are those which are believed to arise from the middle mesoderm layer, which in mature animals and people can be found in bone marrow, fat stores, and connective tissues of all organs. Theyre the ones that are easiest to grow and harvest in large numbers and then package and prepare for therapeutic application. The cells of the other two layers are more difficult to grow to sufficient numbers, and they also cause a greater immune response in the recipient; theres a greater chance of rejection. So in part, the field as a whole has gone down the easiest path, and in part has selected a cell type that is better tolerated by recipients.

Fortunately, the cells of this middle layer the mesenchymal stem cells, or MSCs, as we call them have demonstrated that they have really broad repair potential. They release a lot of chemicals that stimulate the growth of healthy cells in the body. They stimulate wound repair. MSCs are the golden boys of stem cell therapy right now. There are very few stem cells trials right now that arent using them.

Your Dog: Are you saying that stem cells from fat tissue can be taken from a dog and then injected into a sick part of her body, where they grow into healthy cells to help specific body tissue or a diseased organ repair itself?

Dr. Hoffman: Many people have a notion that stem cells have the capacity to convert themselves into a variety of cell types after transplantation and thus resupply cells in damaged tissues such as kidney cells or heart cells or bone. However, only a very small amount of stem cell research right now is directed at what we call engraftment stem cells attaching to particular tissue or organs and then maturing into cells of those organs. Thats not to say that engraftment isnt of great interest. Even here at the veterinary school at Tufts, we have research in place to regrow a lung, a situation that requires engraftment, cell conversion (differentiation), and cell division (proliferation). Scientists at other research institutions are looking at regenerating heart muscle cells or producing retinal cells that engraft and live on in the eye.

This type of research on stem cells as replacement cells is, however, a small fraction of the research that goes into therapies. Certainly, clinical trials are not focused on using stem cells to replace damaged cells, for example, to get a paralyzed animal [or person] to walk again by injecting stem cells into the spinal cord that turn into nerve cells. This is coming; its only a matter of time before scientists perfect growing up a patients own cells to rejuvenate a part of the body that no longer works, or no longer works properly. Currently, though, the majority of stem cell clinical trials are just about getting stem cells to influence damaged or reserve (healthy) cells in a particular part of the body by releasing signals in the form of chemicals. Thats where the momentum is for the foreseeable future. Stem cells in mature fat tissue or bone marrow couldnt even change into other types of cells; thats where youd need more primitive cells such as embryonic or now, reprogrammed embryonic-like cells.

Your Dog: But why would you want stem cells to just release chemicals? What good would that do?

Dr. Hoffman: Chemicals sent forth from MSCs that middle layer of stem cells lodged in fat tissue and bone marrow have the ability to stimulate repair and regeneration of cells already in place. For example, they stimulate new blood vessel formation, or better closure of wounds. Thats currently where their value lies.

Your Dog: Can you give an example of the specific research taking place?

Dr. Hoffman: We have a faculty member at the Cummings School who has just started a clinical trial in which shes looking at the impact of stem cells on the survival of dogs that have life-threatening kidney disease. Again, shes not injecting dogs with stem cells that she hopes will engraft onto sick kidneys and take over for the sick cells, proliferating to the point of growing whole new kidney tissue. Its about getting the stem cells in there to exert a positive effect on the compromised cells that need help, or coax healthy cells that remain to replace damaged cells. In this particular case, we hope that the MSCs reduce an over-active immune system that is attacking the kidneys.

We have another faculty member who is starting a clinical trial to treat an autoimmune liver disease that afflicts Labrador retrievers and is generally fatal. She hopes to arrest liver inflammation and cirrhosis, or scarring also by reducing the immune response.

Your Dog: How is the research done?

Dr. Hoffman: The stem cells either get injected intravenously (as is the case in the examples of clinical trials at Tufts), or at the site of the problem. When injected intravenously, cells home to different parts of the body (e..g., lung, liver, kidney) and release chemicals locally to those tissues. In the scenario when cells are injected directly into tissues, the cells remain in a holding pattern in that region and release their beneficial chemicals there.

Your Dog: What happens to the stem cells after that?

Dr. Hoffman: They die, mostly. Within about 72 hours, most MSCs are gone. Thats why theyre not being looked at for engraftment and cell proliferation. They simply dont last long enough. That would take the other kinds of stem cells, the ones that come from embryonic tissue or newly discovered reprogrammed cells. But theyre much harder to harvest and grow. And unless the cells are harvested ahead of time from the recipient patient, theyre much more prone to rejection by the body into which theyre injected. MSCs, on the other hand, are popular in research because theyre almost devoid of the main trigger for starting an immune response. The immune system of the tissue into which they are injected doesnt recognize them as foreign to the point that they can be used almost interchangeably between patients without worry that a big immune response will make an unhealthy dog even sicker than she already is. There are some minor reactions, but theyre so minor that even multiple injections of the cells generally do not incite a negative reaction.

Your Dog: Why would you inject stem cells multiple times?

Dr. Hoffman: Because they dont last long. If you want a long-term beneficial effect, several, sometimes many, doses of stem cells are needed. It might be 10 to 20 million cells per injection, which isnt a lot.

Your Dog: How have results been so far?

Dr. Hoffman: Results in clinical trials to date have been promising but not conclusive. There are a lot more veterinarians using stems cells in their practices than there are study results to support their use. No clinical trial has as yet proven, without a shadow of doubt, a clear benefit. This is largely due to the limited size of studies, and the fact that important controls were left out. These studies are very difficult to do for the simple reason that these are our companion animals, and no one wants to be included in a clinical trial and receive either unproven or ineffective treatments or placebos (which have no effects), and no one wants their pet to experience adverse side effects.

With that in mind, one of my pet peeves is the current high expense for stem cells where they have not yet been shown to be valuable. Many people fork over $1,500 to $2,500 to treat their dog or their horse with stem cells, and we dont have the clinical trial data to support recommending those therapies. This seems to be mostly the case for musculoskeletal treatments to ameliorate, say, the symptoms of arthritis or tendon injuries. Companies claim they are seeing benefits in patients that are treated with their MSCs, but the publications are not there for dogs (or humans, for that matter) to support this claim. Theres some research out there, and its provocative, but there is always a question about how much money is worth spending on an unproven therapy, which is often the case with new therapies in veterinary medicine. At this point the medical community, both veterinary and otherwise, is simply trying to understand the merits of stem cell treatments. Were trying to design trials that are objective and ethical and wont hurt the patient while allowing us to garner the information we need. At this point, we have a lot of grade C and D evidence out there, not a lot of As and Bs.

It is also important to note that, unlike the situation in human medicine, stem cells are unregulated thus far in veterinary medicine, so the safety and efficacy and protocols used to generate cells by companies is not under intense scrutiny yet. But this will also come. Tufts is preparing for this inevitability by producing cells in-house, and working on new methods to improve quality and potency of the cells.

Your Dog: Where do you see the field of stem cell research headed in, say, five or 10 years?

Dr. Hoffman: Its headed toward reprogramming or activating stem cells to think. This is a very new area. The process of reprogramming stem cells so that they become particular types of cells (heart cells, nerves, etc.) was only first written up in 2006. And here we are now, talking about it, not only within the scientific community but in the lay community, too. I suspect that within the next five to 10 years for MSCs and the next 10 to 20 years for reprogrammed cells, application of stem cells to treat or even cure disease will have been proven and documented and used as a conventional part of veterinary practice.

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Stem Cell Research On Dogs – Tufts Your Dog Article

Lex (dog) – Wikipedia

Lex (1999 March 25, 2012) was the first active duty, fully fit military working dog to be granted early retirement in order to be adopted. Working for his United States Marine Corps handler Corporal Dustin J. Lee in the Iraq War, he was wounded in an attack that killed Lee, and subsequently awarded an honorary Purple Heart.

Lee and Lex were stationed in the military police department at Marine Corps Logistics Base Albany, with Lex having deployed to Iraq previously with a different handler. Lee had adopted his previous canine, Doenja, after the dog was retired.[1] They were detached to deploy in late November 2006 as an explosive detection and patrol team for 3rd Reconnaissance Battalion, then part of Regimental Combat Team 6.[2][3] On March 21, 2007, while at a Forward Operating Base in Iraq, they were hit by a 73mm SPG-9 rocket attack. Lee was mortally wounded, while Lex sustained shrapnel wounds.[3] Despite his own wounds, Lex refused to leave Lee and had to be dragged away for corpsmen and other medics to attempt treatment.[4] After returning to the United States in April, he fully recovered from his wounds at Marine Corps Base Camp Lejeune after a twelve-week rehabilitation. He returned to MCLB Albany on July 6 in a full working capacity, although some shrapnel remained lodged in his back, which veterinarians did not remove to avoid causing permanent damage to his spine.

We are proud to have had Lex serve alongside Marines here and around the world. His handlers and his sacrifices will not be forgotten. I am glad to be able to support the Lee family, not just in the adoption of Lex, but also to reestablish their connection to their beloved son Dustin.

Col Christian N. Haliday, CO of MCLB Albany

Lees parents, Jerome and Rachel Lee, appealed to the military to adopt Lex. An online petition[5] was created by Lee’s family, and the case gained national media attention. Congressman Walter B. Jones of North Carolina’s 3rd congressional district (which includes Camp Lejeune) assisted the Lee family with the release and adoption of Lex.[6] Although the United States armed forces do not generally release military working dogs prior to retirement age due to certain requirements (due to 10 U.S.C.2583[7]), there existed a provision to existing law that allows for early retirement of dogs under certain situations, created to allow a wounded Air Force dog handler to adopt her partner before retirement in 2005.[8][9] The legal provision was enacted and Lex was released from active service to be adopted by the Lee family.[2]

Headquarters Marine Corps made a formal request to the Air Force working dog program managers at Lackland Air Force Base in November, which was approved on December 6. Lex was released from five years of active service and turned over to the Lee family at a ceremony at MCLB Albany on December 21, 2007, under national media spotlight. He was 8 years old at the time. Afterward, Lex began to visit VA hospitals to comfort wounded veterans and assist in their recovery process. On February 16, 2008, the Military Order of the Purple Heart Chapter #566 presented Lex with a commemorative Purple Heart at a ceremony held at the Air Force Armament Museum at Eglin Air Force Base.[10] On September 24, 2008, the American Kennel Club announced that Lex won the seventh Law Enforcement AKC Award for Canine Excellence.[4] On March 19, 2010, MCLB Albany’s base dog kennel was named in honor of Lee, with Lex in attendance.[3]

After his adoption, Lex struggled with mobility issues due to his injuries and approximately 50 pieces of shrapnel that remain in his body, despite treatment at Mississippi State University’s College of Veterinary Medicine. On November 16, 2010, Lex began treatment at Georgetown Veterinary Hospital with a course of Vet-Stem stem cell regenerative therapy, with assistance from the Humane Society of the United States and Kentucky Congressman Ed Whitfield.[11]

Lex died on March 25, 2012 as a result of cancer.

Banner at Lex’s adoption ceremony

CBS News interviews the Lee family and Marine officials at Lex’s adoption ceremony

Police Officer Reynolds prepares to turn over Lex to the Lee family

Jerome Lee receives Lex at the adoption ceremony

Jerome Lee and Lex at the adoption ceremony

Jerome Lee plays with Lex after the adoption ceremony

The Lee children play with Lex after the adoption ceremony

The Lee family with Lex after the adoption ceremony

Lex awarded an honorary Purple Heart

http://www.sunherald.com/2012/04/20/3895746/slain-marines-service-dog-dies.htmlThis article incorporatespublic domain material from websites or documents of the United States Marine Corps.

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Lex (dog) – Wikipedia

Stem cell research | Animal Health Trust

Stem Cell Research

INTRODUCTION

Stem cells have the ability to self-renew and to turn into other types of cells. We are carrying out research into their potential use in veterinary medicine.

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CURRENT RESEARCH

We are currently researching stem cell therapy for horse tendon injuries and fractures in Thoroughbreds.

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SCIENCE PUBLICATIONS

Read our latest publications on our stem cell research.

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MEET THE TEAM

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CONTACT US

If you want further information on the work we’re doing into stem cell uses, then please do get in touch.

Find out more

Stem cells have the ability to self-renew to generate more stem cells and to turn into other types of cells. Broadly, stem cells can be classified into two groups; multipotent stem cells and pluripotent stem cells. Multipotent or adult stem cells exist in many different tissues and can only turn into a limited number of cell types. In contrast pluripotent or embryonic stem cells exist at the very earliest stages of development and can turn into every cell type of the body.

We are carrying out research to use stem cells in veterinary medicine. To date our research has focused on horses and dogs and we have derived pluripotent stem cells from horse embryos and multipotent stem cells from adult horse and dog tissues.

Horse embryo-derived stem cells (ES cells) can be grown indefinitely in the laboratory, express markers associated with pluripotency and can turn many different types of cells. This means they have the potential to be used therapeutically to help regenerate damaged tissues. We have also made horse and dog induced pluripotent stem cells (iPS cells) from adult cells by reprogramming them back to a state where they resemble ES cells. Like ES cells, iPS cells have the potential to be used therapeutically. Furthermore, iPS cells can be isolated from horses and dogs with inherited diseases in order to provide a tool to study that disease in the laboratory.

Horse multipotent mesenchymal stem cells (MS cells) can be isolated from many tissues including the bone marrow and fat tissue of adult horses and the umbilical cord blood of new-born foals.

Tendon injuries occur commonly in racing and sport horses and because the injuries heal through the formation of scar tissue instead of normal tendon tissue they are associated with a high rate of re-injury. Stem cells may help to bring about normal tendon regeneration and therefore reduce the frequency of re-injury. Our research aims to understand the mechanisms by which different types of stem cells work so that we can produce an optimised stem cell therapy for horse tendon injuries.

In current clinical practice horses are treated with their own mesenchymal stem (MS) cells. This requires each horse to have a tissue sample isolated and results in a delay while the cells are processed and grown to sufficient numbers for injection into the tendon. The advantage of embryo-derived stem (ES) cells is that they grow indefinitely in the laboratory and may therefore provide an off the shelf source of cells for treating injuries.

We have shown that ES cells can be injected into the damaged tendons of horses without any undesirable side effects being detected in the 3 month period studied. The ES cells survive in high and stable numbers in the tendon and turn into tendon cells. In the laboratory we have established a 3D culture system to generate artificial tendons from ES cells. We are using this system to determine the signals which drive ES cells to turn into tendon cells to ensure that therapies which use ES cells in the future will be safe and effective.

In contrast to ES cells, MS cells do not turn into tendon cells following their injection into the tendon. However, we have shown that horse MS cells are able to reduce an inflammatory response and they may produce other signals which act to stimulate better tissue regeneration by the bodys own cells.

Fractures caused by bone overloading (as opposed to a direct trauma) are common in racing Thoroughbreds. The risk of fractures is affected by various environmental factors but previous work at the AHT has shown that there is also a genetic risk to fracture in Thoroughbreds.

We are now using iPS cells from horse at high and low genetic risk of fracture to generate bone in the laboratory. This will allow us to determine the biological mechanisms which are affected in high risk horses and understand why these horses are predisposed to fracture.

In the future this will enable the design and application of management techniques to minimise the risk of fracture in horses.

The cornea allows light to be transmitted into the eye. In corneal stromal dystrophy, fat deposits inside the tissue and can lead to ulceration and impaired sight. It occurs in many dog breeds and there are no treatment options available. Corneal transplantation is hampered by a shortage of donor material.

We are carrying out research to study corneal stromal stem cells and produce corneal stromal cells in the laboratory from dog induced pluripotent stem cells (iPSCs). These cells will provide a new tool to enable future studies of this disease to better understand what causes it and if it could be prevented.

The production of corneal cells may also provide a new transplantation therapy for dogs with corneal damage resulting from injury or disease. This work is being performed in collaboration with Professor Julie Daniels, Institute of Ophthalmology, University College London.

Paterson, Y. Z., Kafarnik, C. & Guest, D. J. (2017) Characterisation of companion animal pluripotent stem cells. Cytometry A. doi: 10.1002/cyto.a.23163.

Bavin Emma P., Atkinson Francesca, Barsby Tom, and Guest Debbie J.. Stem Cells and Development. January (2017) Scleraxis Is Essential for Tendon Differentiation by Equine Embryonic Stem Cells and in Equine Fetal Tenocytes

Bavin, E. P, Smith, O., Baird, A.E, Smith, L.C., & Guest, D.J. (2015) Equine Induced Pluripotent Stem Cells have a Reduced Tendon Differentiation Capacity Compared to Embryonic Stem Cells. Frontiers in Veterinary Science, 2, 55.

Broeckx, S.Y, Borena, B.,Van Hecke, L., Chiers, K., Maes, S., Guest, D.J., Meyer, E., Duchateau, L., Martens, A., & Spaas, J.H. (2015) Comparison of autologous versus allogeneic epithelial-like stem cell treatment in an in vivo equine skin wound model. Cytotherapy. 17(10):1434-46

Baird, A.E.G, Barsby, T. & Guest, D.J. (2015) Derivation of canine induced pluripotent stem cells. Reproduction in Domestic Animals. ;50(4):669-76.

Paterson Y. Z., Rash, N., Garvican, E. R., Paillot, R., & Guest, D.J. (2014) Equine mesenchymal stromal cells and embryo-derived stem cells are immune privileged in vitro. Stem Cell Research and Therapy. 5, 90.

Barsby, T., Bavin, E. & Guest, D. J. (2014) 3-Dimensional Culture and Transforming Growth Factor Beta3 Synergistically Promote Tenogenic Differentiation of Equine Embryo-Derived Stem Cells. Tissue Engineering Part A. 20, 2604-2613.

Broeckx, S., de Vries, C., Suls, M., Guest, D. J., Spaas, J. H. (2013) Guidelines to Optimize Survival and Migration Capacities of Equine Mesenchymal Stem Cells. J Stem Cell Res Ther 3: 147.

Barsby, T. & Guest, D. J. (2013) Transforming Growth Factor Beta3 Promotes Tendon Differentiation of Equine Embryo-Derived Stem Cells. Tissue Engineering Part A. 19(19-20)2156-2165.

Spaas, J. H., Guest, D. J., Van de Walle, G. R. (2012) Tendon Regeneration in Human and Equine Athletes: Ubi Sumus-Quo Vadimus (Where are We and Where are We Going to)? Sports Medicine. 42(10)871-890.

Guest, D. J., Smith, M. R. W. & Allen, W. R. (2010) Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendons. Equine Veterinary Journal. 42(7), 636-642.

Guest, D. J., Ousey, J. C., and Smith, M. R. W. (2008) Defining the expression of marker genes in equine mesenchymal stromal cells. Stem Cells and Cloning: Advances and Applications. 1, 1-9.

Guest, D. J., Smith, M. R. W., and Allen, W. R. (2008). Monitoring the fate of autologous and allogeneic mesenchymal progenitor cells injected into the superficial digital flexor tendon of horses: preliminary study. Equine Veterinary Journal. 40, 178-181.

Guest, D. J. and Allen, W. R. (2007). Expression of cell-surface antigens and embryonic stem cell pluripotency genes in equine blastocysts. Stem Cells and Development. 16, 789-795.

Greenway, D. J. & Allen, W. R. (2007). Horse stem cells in development and therapies. Reproduction in Domestic Animals. 42(Suppl. 2) 68-68.

For further information please contact

Dr Debbie Guest

debbie.guest@aht.org.uk

+44(0)1638 750000 ex. 1283

Write to us at:

Animal Health Trust

Lanwades Park

Kentford, Newmarket

Suffolk

CB8 7UU

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Stem cell research | Animal Health Trust

Snuppy – Wikipedia

Not to be confused with Snoopy.

Snuppy (Korean: a portmanteau of “SNU” and “puppy”; April 24, 2005May 2015)[1] was an Afghan hound, credited with being the world’s first cloned dog. The puppy was created using a cell from an ear from an adult Afghan hound and involved 123 surrogate mothers, of which only three produced pups (Snuppy being the sole survivor). Department of theriogenology and biotechnology at Seoul National University for cloning Snuppy was led by Woo Suk Hwang. Snuppy has since been used in the first known successful breeding between cloned canines, after his sperm was used to artificially inseminate two cloned females, which resulted in the birth of 10 puppies in 2008.

After Dolly the sheep was cloned in 1996, scientists had managed to clone numerous other animals, including cats, cows, gaur, horses, mice, mules, pigs, rabbits and rats[2] but had been unable to successfully clone a dog due to the problematic task of maturing a canine ovum in an artificial environment.[2] After several failed attempts by other scientists, Woo Suk Hwang, a lead researcher at Seoul National University, was able to successfully create a clone using tissue from the ear of a 3-year-old Afghan hound.[3][4] 123 surrogate mothers were used to carry the embryos, of which 1,095 were implanted, the procedure resulted in only three pregnancies; one resulted in a miscarriage, the other pup was born successfully but died of pneumonia three weeks after birth, the successful clone was carried by a Labrador Retriever.[2] From the original 1,095 embryos to the final two puppies, this placed the success rate of the project at less than two tenths of a percent.[3] Snuppy was named as a portmanteau of the initials of the Seoul National University (SNU) and the word “puppy”.[5]

As the eggs in a female canine are only fertile during the estrus phase of the estrous cycle, the eggs could only be harvested during a three-week period each year. Due to complexities with removing eggs from canine ovaries the eggs had to be extracted from the oviduct, which required constant monitoring to achieve.[6] The nucleus of each egg was replaced with the cell from the ear of the adult dog and then electrified and fused using a chemical reaction. The embryos were then transferred to the surrogate dogs. Three of the surrogate mothers became pregnant and two successfully gave birth. Snuppy, the first to be born, survived while the other died two weeks after birth.[6] This process of cloning Snuppy took nearly three years of intensive effort.[7]

Snuppy was named as Time Magazine’s “Most Amazing Invention” of the year in 2005.[3] Particular recognition was given to the cloning technique used in the process, which Time stated was “embodied by a history-making puppy”. Despite numerous labs performing mammalian cloning, they cited that Hwang’s team and Snuppy were “extraordinary”.[6][8] The experiment was criticised by Robert Klitzman, director of Columbia University’s Masters in Bioethics program, who cited that the process raised the question of if humans are “just a mass of cells and biological processes?”[6] Hwang himself criticised the process, stating that it did not bring science any closer to human cloning and the complexities, coupled with the low success rate (one in 123), did not make it ethical to clone family pets.[2] Ian Wilmut, the scientist behind the successful cloning of Dolly the sheep, said that the successful cloning of Snuppy proved that any mammal could be cloned in the correct environments and that a global ban on human cloning needed to be quickly implemented because of this.[2] The Kennel Club criticised the entire concept of dog cloning, on the grounds that their mission is to “To promote in every way the general improvement of dogs” and no improvement can occur if replicas are being created.[4]

Between late 20052006 Hwang was accused of a series of misconducts. The first allegations related to his work prior to Snuppy; the claim that he had successfully cloned a human embryo. The charges alleged Hwang had paid for egg donations and that some of eggs came from his employees, which constitute serious breaches of the code of bioethics. It was later found that photographs he published did not depict what was suggested and that most of the stem-cell lines he claimed to have created were not clones at all.[9] This brought serious doubts onto the validity of Snuppy, which Hwang consistently claimed was a genuine clone. Hwang hired HumanPass Inc., a Korean DNA lab to investigate Snuppy, who found that Snuppy was authentic. The findings by HumanPass were dismissed on the grounds that they were employed by Hwang, and a panel at the Seoul National University ordered their own investigation.[10] The investigation found that, despite his fabrications in previous projects, Hwang’s research related to Snuppy was accurate and Snuppy was a clone of the adult Afghan hound.[11] As a result of his forgeries, Hwang was indicted for fraud and dismissed from the university.[12]

Veterinary professor Byeong Chun Lee took over leadership of the team behind Snuppy.[13] In 2008, Snuppy became involved in the first known successful breeding between cloned canines, after sperm taken from Snuppy was used to artificially inseminate two cloned females, which resulted in the birth of 10 puppies.[14] Nine of the puppies survived.[15] The SNU team, under Lee, have gone on to successfully clone over 30 dogs and five wolves.[16] After successfully breeding the cloned wolves, Lee claimed that the ability to breed cloned canines makes it possible for working dogs which are usually sterilised before training, such as sniffer dogs and guide dogs, to reproduce.[17] SNU, which claimed to own the patent for the process used to clone Snuppy, formed a license agreement with RNL Bio, a commercial pet cloning company. Hwang entered into a partnership with RNL Bio’s competitor, BioArts International, which caused an ongoing legal battle into who owns the patent rights[12][18] although Bio Arts withdrew from dog cloning in 2009.[19] RNL completed the first commercial cloning in August 2008[20] but ran into financial trouble in 2013.[21]

The world’s first cloned sniffer dogs (all of which are named Toppy) were put to work by South Korean customs in July 2009.[22]

Supporters of Hwang founded a company called Sooam Biotech where Hwang developed proprietary techniques[23] based on a licence from ViaGen’s subsidiary Start Licensing (which owns the original Dolly patent[24]) and created cloned dogs for owners whose dogs had died, charging $100,000 a time[25] Sooam Biotech was reported to have cloned 700 dogs by 2015[25] and to be producing 500 cloned embryos of various species a day in 2016.[26]

Snuppy died in May 2015 at the age of 10.[27]

Link:
Snuppy – Wikipedia

Stem Cell Docu Series

Jeff Hays is a filmmaker and a serial entrepreneur. He began making films back in the late nineties. Hes best known for Fahrenhype 9/11 (2004), a response to Michael Moores Fahrenheit 9/11, and On Native Soil (2006), a documentary focusing on the passionate demand of the surviving family members of 9/11 victims for an official investigation into the 9/11 attacks. This documentary, which was narrated by Kevin Costner and Hillary Swank was short-listed for an Academy Award in 2005.

Hays recent health documentary releases are Bought, Doctored, Undoctored, Rigged 2016 and the GMOs Revealed and Vaccines Revealed series programs. Hays explains, In recent years my eyes have been opened to alternative healthcare options. The immediate increase in health I experienced personally after starting down this road is something Ive just got to share with people.

Hays most recent release is Christ Revealed, a 9-episode docuseries featuring exclusive expert interviews and a stunning tour of Israel.

Also, Chasing the Scream, the New York Times Best Selling book by Johann Hari is being brought to life by Jeff Hays Films and is now in pre-production with Academy Award winning co-producers and Academy Award nominated directors attached.

Two additional documentary series from Jeff Hays Films are being released in early 2018. The Healing Miracle: the truth about stem cells, and The Real Skinny on Fat, the truth about weight loss.

A pet project is Movie Maker Academy where Hays is on the faculty teaching filmmakers and entrepreneurs how to create successful donor crowdfunding projects based on his 7-figure success in crowdfunding.

Hays lives in the mountains of Utah with his dog Abby and works from his office in NY. Hes the father of 9, and grandfather of 12, with new ones annually

Original post:
Stem Cell Docu Series

Stem Cell Therapy for Dogs and Cats – Vet4Bulldog

Stem Cell Therapy for dogs and cats, bulldogs and other pets.Dr. R. Kraemer, veterinarian and owner of Vet4HealthyPet Advanced Medical Care Pet hospital located at 434 South Tustin Street at theCity of Orange inOrange County, California,has provided veterinary services since 1992 for dog, cat and other pet owners and is now a leading provider for stem cell therapy for dogs and cat. Due to increased demand, Dr. Kraemer is expanding the offer for this groundbreaking, regenerative medicine and cryobanking to pet owners from anywhere in the State of California, as well as those out of state who are unable to find Stem Cell treatment/therapy for dogs and cats (their pets) from their local veterinarians.

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Stem Cells for dogs and cats are extracted from your pets fatty tissue, and processed with Platelet Rich Plasma (PRP)into an injectable solution, which is then activated using LED Light technology. Following activation, the solution is then injected intra-articular (i.e. directly into arthritic joints) as well as intravenously. This is a same day procedure with no serious side effects, no extensive recovery time, or confinement needed.

Stem Cell Therapy for Dogs and Cats: Dr. Kraemer is a leading provider for Stem Cell Therapy treatment for dogs and cats (pets)

Economical Quality of Life Enhancement Minimal Confinement Minimal Post-Op Recovery Time No Post-Op Rehabilitation

Stem Cell Therapy by Dr. Kraemer for Arthritis, Hip Dysplasia and Degenerative Joint disease in Pets

Promising results forstem cell therapy for dogs and catscurrently shown in Clinical trials-Case studies-Peer review-Compassionate use:

Dr. Kraemer extracting the stem cells from his pet patient adipose tissue

I sat down for a Q&A with three bulldog rescue members who whose pets I have treated with stem cells for various medical conditions. Southern California Bulldog Rescue is a non for profit rescue organization dedicated to providing deserted and abused bulldogs with medical care, housing, and placement with new families. I have a close relationship with SCBR and have been providing medical care for their rescued pets for many years andshelter and at my new 434 south Tustin street, orange, Ca. veterinary hospital. If you would like to help SCBR and bulldog rescue, we invite you to join our U4B Pledge. SCBR also accepts donations, which are deductible to the full extent of the law.

Vicky (SCBR): Dr. Kraemer what are stem cells?

Dr. Kraemer Answers: Stem cells are the bodys repair cells we all have waiting to be called on when injury occurs and as our body ages (wear & tear). Stem Cells have the ability to divide and differentiate into many different types of cells based on where they are needed throughout the body. Stem cells can divide and turn into tissues such as skin, fat, muscle, bone, cartilage, and nerve, to name a few. They even possess the ability to replicate into organs such as the heart, liver, intestines, pancreas, etc.

Ronnie (SCBR): What the term RegenerativeMedicine means?

Dr. Kraemer Answers:Its theuse of our own cells to augment or stimulate the bodysnatural healing processes. Regenerative medicine is the process of creating living, functional tissues torepair or replace tissue or organ function lost due to age, disease, damage, or congenital defects.

Nicole (SCBR): A friend of mine had banked her newborn child stem cells from her own placenta and umbilical cord, are yours the same kind of stem cells?

Dr. Kraemer Answers: There are two basic types of stem cells; embryonic and somatic (adult). Embryonic Stem Cells are found in the placenta, umbilical cord and embryo, these cells are called totipotent, which means they have the ability to reproduce into any mature cell type. While Embryonic Stem Cells offer the greatest potential in healing, there are obviously moral and ethical concerns in harvesting these cells.

The second type of stem cell is the Adult Stem Cell, these stem cells are called multipotent, which means they can differentiate into closely related cell lines, but they are not capable of creating a complete organ. Adult Stem Cells are found in the bone marrow, adipose tissue (fat), skin, liver, blood vessels, and neurons. Contrary to embryonic stem cells, there are NO moral or ethical concerns in harvesting Adult Stem Cells, activating them, and reintroducing them back to the patient in areas where healing and regeneration is needed.

Ronnie (SCBR): So Dr. Kraemer why you prefer extracting the stem cells from adipose (fat) tissue?

Dr. Kraemer treating a dog patient with stem cell therapy for joint disease and arthritis

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): Adult stem cells are highly concentrated in the fat tissue. There are 50 to 1,000 times more stem cells in the fat than the bone marrow. At this concentration, it is no longer necessary to culture the stem cells to acquire the necessary cell numbers to make a healing impact. Compare to harvesting from bone marrow Adipose tissue is easier to get, less painful and involve lower risk while yielding many more stem cells compared to bone marrow. On matter of speed and degree of risk this procedure (i.e. to extract fat from your pet) is much quicker and less invasive than even a routine spay. The stem cells are contained within a pool of cells in the fat termed the Stromal Vascular Fraction (SVF)which includes bone marrow stromal cells and mesenchymal cells along with many beneficial proteins that on cellular level encourage:

Stem Cell in action (microscopic view)

Nicole (SCBR): Dr. Kraemer, can you explain how Stem Cells work and how would they help our pets?

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): Stem Cells work like heat-seeking guided missiles, only in this case they are seeking damaged, injured, aging cells in urgent need of repair. Their repair abilities are multi-factorial which include among other,

Adult stem cells are capable of dividing into many different cell types. With this capability, we can use them as a treatment for joint injuries, ligament, tendon damage, and fractured bones. Stem Cell therapy also has shown promise for renal disease, dermatological conditions, and muscle tear repair.

Ronnie (SCBR): Which dogs and cats are the best candidates for Stem Cell Treatments?

Dr. Kraemer Answers:Dogs and cats that have not responded well to non-steroidal anti-inflammatory (NASID) drugs and other pain medication and continue to suffer from debilitating pain.

Stem Cells in action at the cellular level

Vicky (SCBR): Dr. Kraemer what makes the stem cell technology you are implementing superior to other stem cell therapies currently available in veterinary practice?

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): I am one of the few doctors in our area who are certified by MediVet Americas technology. MediVet is a patented L.E.D. technology incorporating Platelet-Rich Plasma (PRP) the same treatment used by many sports professionals. MediVet America is able to acquire the most living stem cells of any company currently offering this technology. There is no stem cell lost due to transportation and poor handling since I have my own in-house fully equipped specialized laboratory. That is a big advantage over all the other systems since they require you to ship the fat to an outside lab for the extraction and processing. This delay will cause cell death and force the client to bring his pet back the next day for the final injectable process (i.e. treatment) .

Nicole (SCBR):Can stem cells be banked and used again to treat future problems and repeat treatments?

Dr. Kraemer answers (Stem Cell Therapy for dogs and cats):In collaboration with MediVEt America Ioffer Cryobanking, where you can store extra cells from the procedure for future use. Many of our clients whove had their pet treated with stem cells opted to cryobank some or their pets stem cells for future treatments. Most of the time we can get up to six additional treatments from the cryobanked stem cells.

Ronnie (SCBR): Dr. Kraemer, can you tell us how long the procedure takes and what it entails?

Dr. Kraemer holding a Platelet Rich Plasma (PRP) vial ready to be mixed up with his patient stem cells

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): The day of the procedure you will bring your pet to our Animal Hospital. We will first fit them with an IV catheter through which we will administer fluids and pre-op pain medication. We will then anesthetize your pet just long enough (about 15 min) so as to alflow me to surgically remove a couple of tablespoons of fat. This is a quick and simple procedure that is generally easier than performing a typical spay. Dr. Kraemer and his staff at the Animal Hospital will then process the fat at the in-house lab in order to extract the stem cells using MediVet patented kit. They will then be mixed withPlateletRich Plasma extracted from your pets own blood. The whole process takes a couple of hours. Just before those final highly concentrated, pure stem cells are ready to be injected, we will activate them to become supercharged (i.e. super-excited) with a special L.E.D light. During the final step your pet will be mildly sedated, and will receive pain medication for comfort. The stem cells will then be administered into the affected joints and/or into the bloodstream intravenously. It is important that you do not feed your pet the night before the procedure

Vicky (SCBR): Dr. Kraemer, do you guarantee success, and how soon is it before most pet owners will notice an improvement?

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): There are no guarantees, as each pet is different. Nationwide, 95% of procedures for osteoarthritis and hip dysplasia have shown clinical improvement. Some pet owners report seeing a difference in as little as a week. Others do not see a change for a month or two. If your pet is going to show improvement, we expect that it will occur within the first 90 days following treatment. Really bad arthritis may require multiple injections, so banking your extra cells is always a good idea.

Nicole (SCBR): Dr. Kraemer can you go over any safety concerns some pet owners might have?

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): As with any procedure that involves anesthesia, even one with as short of duration as this one, there is always some risk factor involved. However, the stem cells are coming from your pet (Autologous) and are being re-administered back to your pet. There is no risk of an allergic reaction, no cell rejection or disease transmission. Rarely, there might be a mild immune reaction in the injected joint that should subside within a day or two.

Ronnie (SCBR): I think most of us who have had our pet treated are excited about this new age therapeutic modality, yet cost is still an important factor in a pet owners final decision. Can you tell us how much will this cost?

Dr. Kraemer actives (super charges) his patient stem cells with LED light

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): Think about it this way, a young pet diagnosed with osteoarthritis may require surgical intervention, rehabilitative therapy, and potential lifelong prescription for pain medication. The cost of Stem Cell therapy would be less, and cells can be stored for the lifetime of the animal and used again at a much lower cost than the initial process. Its also important to remember the potential complications with surgeries like infection, implant failure and soft tissue trauma, plusrecovery is lengthy aftersurgery and requires weeks of strict confinement. And in regards to long term painmanagementmedication, even the new generation pain relief drugs can have adverse effects, requiremonitoring, and, in some cases, can lead to serious health complications. Our Pet Hospital offers two different sized stem cell kits for pets.

The difference in cost between the two kits is ONLY 300 dollars (i.e. double the stem cells for only an additional 15% extra above the small kit cost). Hence, for most cases the LARGE stem cell kit is by far the better choice, allowing us to inject the maximum amount to multiple joints and still have plenty left to give intravenously or/and store (cryobank) some for years to come.

Ronnie (SCBR): Speaking about cost, is stem cell therapy covered by the various pet insurances?

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): Great question and very timely. Yes most pet insurance companies cover stem cells in treatment as long as the disease itself is covered by the policy.

Nicole (SCBR): Lately I have been hearing on the news about many new life saving medical applications and discoveries with stem cells. How do you see the future of stem cell therapy?

Dr. Kraemer Answers (Stem Cell Therapy for dogs and cats): I am glad you brought it up Nicole. Regenerative medicine is in its infancy, and has unlimited potential. In the coming years, I foresee a major advance into every day practice with a much wider range of therapeutic applications available. So I believe it is here to stay. As the body of science in veterinary stem cell therapy increases, I envision more and more pet owners opting for collecting stem cells prophylactically when their pet is being spayed or neutered, and storing the cells for later indications and uses. Future science will likely prove that stem and regenerative cell therapies should be part of multimodal approaches to increase chances for the best outcome for many veterinary patients.

Dr. Kraemer is a leading provider of stem cell therapy for the use of Osteoarthritis injuries and pain in pets

Vicky (SCBR):Thank you, Dr. Kraemer, for your time and for all the help you and your staff have provided our rescue over the years. I also wanted to personally thank you and MediVet of America for what you did for our Piper, if it was not for stem cell therapy she would have not been with us. You made me a believer. Any final thoughts?

Dr. Kraemer (Stem Cell Therapy for dogs and cats): Thank you Vicky for the kind words,it is a true privilege to be part of the SOUTHERN CALIFORNIA BULLDOG RESCUE organization.In veterinary medicine, while many of the compassionate cases outcomes are anecdotal, we still lack solid scientific trials to prove efficiency, though more of them are being conducted now by universities around the country. Stem cells have already shaped the contemporary medicine of humans and should, sometime soon, do the same in veterinary medicine, with more clinical trials done in laboratory settings. I have been treating compassionate cases who came to me after traditional medicine failed, leaving them with euthanasia as the only human option. Such was the case of Vickys (Southern California Bulldog Rescue)Piperan English bulldog who was treated by multiple internal medicine specialists for IBD (inflammatory bowel disease) for over seven months, prescribed multiple immune suppressant steroids, antibiotics, and a handful of other drugs, homeopathic remedies and special diets and yet continued to show no improvements. Piper was down to 23lb, with protruding bones and explosive, non-responsive diarrhea. To read more about Pipers amazing story ,click here.Among many other compassionate cases,I have also treated a 13 year old Degenerative Myelopathy, a grave, non-treatable condition that was sent home after an MRI with no hope. I also treated an English bulldog with non-responsive, erupting and painful interdigtial cysts who developed serious complications due the immune suppressant drugs he was on, and other cases, many of which I will present on this site in coming weeks.

I would like to say that we can all eat healthy, exercise regularly and learn to relax in order to improve our life quality and increase longevity. The same goes for our pets. But as most of us are painfully aware, injuries and illness could happen despite our best efforts to live a healthy lifestyle. Many times surgery will be recommended, and there are certainly many times when surgery is appropriate and needs to be performed. We should all be VERY grateful we have access to this tool. Nevertheless, I am a big advocate and strongly believe in awareness of other, less invasive, safer, often less costly, effective, alternative options. The latest therapeutic modalities like stem cell therapy, Platelet Rich Plasma, and class-4 Cold Laser Therapyare here to stay, and its only the beginning. I predict that in the coming decade, those new age modalities will be main stream and an integral part of every hospitals medical services. With the rise of regenerative medicine it is sufficient to say that you are witnessing the emergence of a completely new age in healing and certainly a total paradigm shift in veterinary health care.

Recognizing the success of regenerative medicine in humans (notable examples include bone marrow transplantation, work done on heart cells, skin and corneal regeneration) there is no doubt in my mind that we will continue to see a robust usage with increasingly wider medical applications. Regenerative medicine is growing rapidly, and it may replace or influence many current treatments giving new and exciting therapeutic modalities to pet owners.

Excerpt from:
Stem Cell Therapy for Dogs and Cats – Vet4Bulldog

Stem Cell Therapy in Dogs – Procedure, Efficacy, Recovery …

As degenerative joint disease is a natural part of the aging process, preventing it is challenging, and these preventative measures can only be effective to a certain extent. Building and maintaining muscles, tendons and joints can be the most effective measure an owner can take. This entails regular exercise for the dog. The frequency, durations and intensity should be varied depending on the dog, but exercise will ensure the muscles and limbs are as healthy as possible for as long as possible. This measure also comes with the benefit of keeping owners fit and healthy. On top of regular exercise, massaging the dog, undertaking at-home strengthening exercises and water therapy may also help to prevent arthritis in the long term.

The next step for owners to take is to alter their dogs diet. Carbohydrates should be discouraged as they promote inflammation. Fresh foods that are unprocessed, are rich in unadulterated enzymes and can help to reduce inflammation. A healthy, balanced diet is key to the long-term health of the dogs muscles and joints.

Certain supplements can also be added to the dogs diet, to encourage muscle and joint retention and prevent degeneration. These are known as joint supportive agents, and common, effective agents are eggshell membrane, glucosamine sulfate with MSM, and cetyl myristoleate.

Both the exercise measures outlined above and the diet alterations may not prevent degeneration entirely, but they may well prevent it occurring until dogs are much older.

The rest is here:
Stem Cell Therapy in Dogs – Procedure, Efficacy, Recovery …

Can Stem Cell Plant-Based be an Alternative to Embryonic …

What is Plant Based Stem Cell Therapy?

Plant based stem cell nutrition are nutritional substances from plants that have been shown to support the release,and activity of your body’s own adult stem cells. This supplement supports wellness by assisting the body in its ability to maintain healthy stem cell physiology, production, and placement. Just as antioxidants are important to protect your cells from free radical damage, stem cell nutrition is equally important to support your stem cells in maintaining proper organ and tissue functioning in your body.

Plant extract stem cell enhancers is the ideal alternative to the embryonic stem cells therapy as ethical concerns have slowed embryonic medical research into applications for stem cells. Also, the embryonic stem cells can unpredictably cause cancer in the treated patient.

The theory that Adult Stem Cells are nothing less than the human body’s natural self-renewal system has profound implications for every area of modern medicine. The idea that heart disease, diabetes, liver degeneration, and other conditions could be things of the past is no longer science fiction; because of recent Adult Stem Cell research breakthroughs, these are real possibilities in the short term.

New research demonstrate that plant based stem cellextract derived from aqua botanical source supports the natural role of adult stem cells. These plant stem cell extracts are typically derived from certain edible algae that grows in fresh water.

When there is an injury or a stress to an organ, compounds are released that reach the bone marrow and trigger the release of stem cells. Stem Cells can be thought of as master cells. Stem cells circulate and function to replace dysfunctional cells, thus fulfilling the natural process of maintaining optimal health

The health benefits of having more stem cells in the blood circulation have been demonstrated by numerous scientific studies. It would be too long here to summarize this vast body of scientific data.I simply suggest you research the work of Dr. Donald Orlic at the National Institute of Health.

Dr. Robert Sampson, MD on stem cell nutrition – “… we have a product that has been shown and demonstrated in the patent to increase the level of adult circulating stem cells by up to 30%. It seems to me we’re having a great opportunity here to optimize the body’s natural ability to create health.”

Stem cells are defined as cells with the unique capacity to self-replicate throughout the entire life of an organism and to differentiate into cells of various tissues. Most cells of the body are specialized and play a well-defined role in the body. For example, brain cells respond to electrical signals from other brain cells and release neurotransmitters; cells of the retina are activated by light, and pancreatic -cells produce insulin. These cells, called somatic cells, will never differentiate into other types of cells or even proliferate. By contrast, stem cells are primitive cells that remain undifferentiated until they receive a signal prompting them to become various types of specialized cells.

Dr. Cliff Minter – “Stem cells are the most powerful cells in the body. We know that stem cells, once they’re circulating in the bloodstream, will travel to any area of the body that has been compromised or damaged and turn into healthy cells. There have been controversial discussions about the new stem cells found in embryos, but the truth is that everyone has adult stem cells in their own bodies. We are all created from stem cells.

As a child or a young adult, your body automatically releases stem cells whenever you injure yourself. That’s why you heal so fast when you are younger. After about age 35, we don’t heal as fast anymore, because the stem cells aren’t released the same way as when we are younger. Stem cell nutrition helps all of us heal our bodies. If you look at the New England Journal of Medicine, you’ll find that the number one indicator of a healthy heart is the number of stem cells circulating in the body. Stem cell nutrition is the organic and all-natural way to stimulate the bone marrow to release adult stem cells into the bloodstream.

By taking stem cell nutrition, you can maintain optimum health and aid your body in healing itself. It’s certainly a better way to recuperate from an illness than using prescription drugs, because even when a medication works, it can often be hard on your liver and the rest of your body. Stem cell nutrition has no negative side effects. This makes it a powerful approach to healing and good health in general.

I found out about stem cell nutrition after someone asked for my opinion on it. I did some research and found it to be one of the greatest ways to slow down aging that we have. Aging is nothing more than the breakdown of cells. Stem cell nutrition combats that action. As cells break down, stem cell nutrition replaces them with healthy cells. This is the greatest, most natural anti-aging method I know. I was skeptical at first, but the results I’ve personally seen in people I’ve talked with have been wide-ranged. Lots of people have reported an increase in energy and better sleeping patterns.

I’ve seen people with arthritis in various parts of their bodies reverse the disease, and people with asthma end up with their lungs totally clear. One person that was on oxygen almost 24/7 is now totally off of oxygen. Two ladies who suffered badly from PMS told me they were 100 percent symptom-free within weeks of starting the stem cell nutrition. Two people I know had tennis elbow which usually takes about six to nine months to heal. Within weeks of taking stem cell nutrition, both report their “tennis elbow” is gone. It makes sense, because stem cells go to whatever area is compromised and turn into healthy cells.

I use stem cell nutrition as a preventative. I’ve noticed an increase in my energy level and an improved sleeping pattern. Stem cell nutrition has zero negative side effects, is very powerful, and we know how it works. It’s good for children as well as adults. This is the best, most natural way I know to optimum health. If you just want to use it for prevention, this is the best thing I know for staying healthy. And if you do those and regaining optimum health. I recommend it to everybody.”

Dr. Cliff Minter (retired) graduated from Illinois College of Podiatric Medicine. He completed his residency at the Hugar Surgery Center in the Hines Veteran Administration Hospital in Illinois before going into private practice in Ventura, CA. Dr. Minter is a national and international speaker on the subjects of business and nutritional products.

The Stem Cell Theory of Renewal proposes that stem cells are naturally released by the bone marrow and travel via the bloodstream toward tissues to promote the body’s natural process of renewal. When an organ is subjected to a process that requires renewal, such as the natural aging process, this organ releases compounds that trigger the release of stem cells from the bone marrow. The organ also releases compounds that attracts stem cells to this organ. The released stem cells then follow the concentration gradient of these compounds and leave the blood circulation to migrate to the organ where they proliferate and differentiate into cells of this organ, supporting the natural process of renewal.

Most of the cells in the human body are specialists assigned to a specific organ or type of tissue, such as the neuronal cells that wire the brain and central nervous system. Stem cells are different. When they divide, they can produce either more stem cells, or they can serve as progenitors that differentiate into specialized cells as they mature. Hence the name, because specialist cells can “stem” from them. The potential to differentiate into specialist cells whose populations in the body have become critically depleted as the result of illness or injury is what makes stem cells so potentially valuable to medical research.

The idea is that if the fate of a batch of stem cells could be directed down specific pathways, they could be grown, harvested, and then transplanted into a problem area. If all went according to plan, these new cells would overcome damaged or diseased cells, leading to healing and recovery. “The life of a stem cell can be viewed as a hierarchical branching process, where the cell is faced with a series of fate switches,” Schaffer says. “Our goal is to identify the cell fate switches, and then provide stem cells with the proper signals toguide them down a particular developmental trajectory.”

Stem cells have the remarkable potential to develop into many different cell types in the body. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function. Scientists believe it should be possible to harness this ability to turn stem cells into a super “repair kit” for the body.

Scientist and author Christian Drapeau explains how the Stem Cell enhancers function to maximize human performance – Supporting the release of stem cells from the bone marrow and increasing the number of circulating stem cells improves various aspects of human health. For very active and sports focused people, Stem Cells are the raw materials to repair micro-tears and micro-injuries created during training. The results, according to Drapeau, are that active people, whether former NBA stars or amateur weekenders, can exercise more intensely at each training session with the ultimate consequence of greater performance.

Theoretically, it should be possible to use stem cells to generate healthy tissue to replace that either damaged by trauma, or compromised by disease. Among the conditions which scientists believe may eventually be treated by stem cell therapy are Parkinson’s disease,Alzheimer’s disease, heart disease, stroke, arthritis, diabetes, burns and spinal cord damage.

Both of my big dogs have gained their youth back. I am a true believer in Stem Cell Nutrition for pets as it has provided a spectacular change in both Ginger and Rowdy. Sonya, IN

Stem cell nutrition for dogs, horses and other animals are specially formulated to be a delectable treat for your animal. The pet chewables and equine blends make it easy to provide your animals with this valuable nutritional supplement. The most common story is that of old, tired and sluggish dogs turned within a week or so into active, alert dogs running around like puppies. The same was observed in horses. Old horses who used to remain standing in the barn or under a tree, sluggish or stricken by too much discomfort to walk around, suddenly began moving about, and at times running and bucking like young colts. One of the most common reports was obvious improvements in hoof health and coat appearance.

times. When there is an injury or a stress to an organ of your beloved pet or horse, compounds are released that reach the bone marrow and trigger the release of stem cells. Stem Cells can be thought of as master cells. Stem cells circulate and function to replace dysfunctional cells, thus fulfilling the natural process of maintaining optimal health.

As they do in humans, adult stem cells reside in animals bone marrow, where they are released whenever there is a problem somewhere in the body. Looking back on stem cell research, we realize that most studies have been done with animals, mostly mice, but also with dogs, horses, pigs, sheep and cattle. These studies have revealed that animal stem cells conduct themselves the same way human stem cells do. When there is an injury or a stress to an organ of your beloved pet or horse, compounds are released that reach the bone marrow and trigger the release of stem cells. The stem cells then travel to tissues and organs in need of help to regain optimal health.

Eve-Marie Lucerne – Eve-Marie keeps nine horses, all older thoroughbreds, and was eager to participate in the trials of a new stem cell enhancer for horses. She shared her allotment of test products with a few large commercial thoroughbred farms, veterinarians and other horse people she knows, and has been pleased with the consistently excellent results she has seen and others have reported to her. This product will help so many animals, she says, adding, People and animals are more alike than we are different. So it makes sense that a stem cell enhancer for animals with promote their health, too.

Eve-Marie’s Equine Stem Cells Nutrition show dramatic results. For several horses facing serious physical challenges, cases where the animals might have to be put down, we saw a return to quality of life. This did not happen before Equine Stem Cell Nutrition. Eve-Marie says that this turnaround was quick, less than two weeks in many cases, and that the subject horses were back to health and enjoying pasture life within a month. One of the unofficial trial subjects for the equine stem cell nutrition was a 30-year old donkey who was in bad shape, Eve-Marie reports. He had chronic respiratory difficulty and could move about only haltingly. His owner had stem cell enhancer supplements to help with her own serious health challenges and shared it with the donkey. The donkey’s owner says this is the first time she wasn’t sick, and her donkey is walking all around, feeling great an enjoying life again!

Farrier and National Hoof practitioner Stephen Dick received some of the trial product from Eve-Marie, and had good results with the two horses he selected for trial. For a 12-year-old quarterhorse stallion, the equine product brought dramatic results. This horse used to lie down twenty-two hours of the day, because he suffered discomfort whenever he stood, Steve reports, continuing, after a couple of weeks with Equine Stem Cell Nutrition, he was getting up and moving around, showing no discomfort. For a high-spirited mare with a leg problem, the equine product brought about a whole new lease on life, Steve says. This horse had been in a stall for 8 months. After about 6 weeks taking the equine product with her grain, her condition had improved and she was out of the stall, walking around in the pasture again.

Little Joe, a small 18-year-old quarter horse that Judy Fisher bought when he was nearly 400 pounds underweight. You could count his ribs, Judy says, remembering, and his backbone stuck up like a ridge all along his back. He was very, very thin! Little Joe also suffered from breathing problems that kept him lethargic and inactive. Vet-recommended remedies were unsuccessful in changing Little Joe’s physical problems, and the vet told Judy he didn’t expect Little Joe to live through the winter. I figured Little Joe was in such bad shape that anything was worth a try, she says.

She began giving the horse stem cell nutrition with his feed and grain twice a day. Within a couple of weeks, Judy was surprised to see Little Joe beginning to gain weight and run, buck, snort and kick. His breathing was no longer labored and his skin and coat were improving. Within six weeks Little Joe’s overall appearance had changed dramatically. He had put on almost 300 pounds. When his former owner came to visit, Judy says, he didn’t recognize Little Joe. That’s how different he looked!

Sara participated in the stem cell nutrition product trials with her two horses and her 80-pound mixed-breed dog. She noted significant improvement in the health and quality of life for all three animals during the time of the trials. For JJ, Sara’s 18-year old quarterhorse, the equine product brought about improvements in his overall mood, appearance and alertness quickly. He really liked the product from the beginning, Sara reports, pointing out that Hank, her 16-year-old thoroughbred/quarterhorse, had not taken to the taste of it too readily. I was able to slowly wean him on it though, she says. For Hank, the equine product was a balm for the skin problems resulting from his allergy to fly bites.

His skin condition improved dramatically. Sara reports, noting that before the equine product the horse had scratched and bitten himself into ope wounds; after the equine product, the scratching and biting dropped off to almost nothing. Sara also noticed an increase in Hank’s energy and liveliness in the first week on the equine product. The horse’s foot and hip discomforts also responded well, leading to a noticeable increase in his mobility and an overall improvement in his quality of life throughout the two-month study.

Sara gave the pet product to her dog, Roxy, who had suffered for two years with ear problems that led to scratching, often until her skin was raw. Vet-recommended remedies had been temporary, quick-fixes, Sara says, but the discomfort always returned with a vengeance. For the pet trials, Sara gave Roxy two tabs of the product a day for two months, noting this is the only supplement she was getting. Sara says Roxy’s problem with her ears definitely improved, the hair as grown back on her head and ears, and the ear problem has not recurred, adding that Roxy is happier and engaging, more playful.

The National Health Institute lists seventy-four treatable diseases using ASCs in therapy – an invasive and costly procedure of removing the stem cells from one’s bone marrow (or a donor’s bone marrow) and re-injecting these same cells into an area undergoing treatment. For example, this procedure is sometimes done before a cancer patient undergoes radiation. Healthy stem cells from the bone marrow are removed and stored, only to be re-inserted after radiation into the area of the body in need of repair. This is a complex and expensive procedure, not accessible to the average person. However, there is now a way that every single person, no matter what their health condition, can have access to the benefits of naturally supporting their body’s innate ability to repair every organ and tissue using stem cell nutrition.

David A. Prentice, Ph.D. – “Within just a few years, the possibility that the human body contains cells that can repair and regenerate damaged and diseased tissue has gone from an unlikely proposition to a virtual certainty. Adult stem cells have been isolated from numerous adult tissues, umbilical cord, and other non-embryonic sources, and have demonstrated a surprising ability for transformation into other tissue and cell types and for repair of damaged tissues.

A new U.S. study involving mice suggests the brain’s own stem cells may have the ability to restore memory after an injury. These neural stem cells work by protecting existing cells and promoting neuronal connections. In their experiments, a team at the University of California, Irvine,were able to bring the rodents’ memory back to healthy levels up to three months after treatment. The finding could open new doors for treatment of brain injury, stroke and dementia, experts say.

“This is one of the first reports that you can take a stem cell transplantation approach and restore memory,” said lead researcher Mathew Blurton-Jones, a post doctorate fellow at the university. “There is a lot of awareness that stem cells might be useful in treating diseases that cause loss of motor function, but this study shows that they might benefit memory in stroke or traumatic brain injury, and potentially Alzheimer’s disease.”

In the study, published in the Oct. 31 issue of the Journal of Neuroscience, Blurton-Jones and his colleagues used genetically engineered mice that naturally develop brain lesions. The researchers destroyed cells in a brain area called the hippocampus. These cells are known to be vital to memory formation and it is in this region that neurons often die after injury, the researchers explained. To test the mice’s memory, Blurton-Jones’s group conducted place and object recognition tests with both healthy mice and brain-injured mice.

Healthy mice remembered their surroundings about 70 percent of the time, while brain-injured mice remembered it only 40 percent of the time. For objects, healthy mice recalled objects about 80 percent of the time, but injured mice remembered them only 65 percent of the time. The researchers then injected each mouse with about 200,000 neural stem cells. They found that mice with brain injuries that received the stem cells now remembered their surroundings about 70 percent of the time — the same as healthy mice. However, mice that didn’t receive stem cells still had memory deficits.

The researchers also found that in healthy mice injected with stem cells, the stem cells traveled throughout the brain. In contrast, stem cells given to injured mice lingered in the hippocampus. Only about 4 percent of those stem cells became neurons, indicating that the stem cells were repairing existing cells to improve memory, rather than replacing the dead brain cells, Blurton-Jones’s team noted. The researchers are presently doing another study with mice stricken with Alzheimer’s. “The initial results are promising,” Blurton-Jones said. “This has a huge potential, but we have to be cautious about not rushing into the clinic too early.”

One expert is optimistic about the findings. “Putting in these stem cells could eventually help in age-related memory decline,” said Dr. Paul R. Sanberg, director of the Center of Excellence for Aging and Brain Repair at the University of South Florida College of Medicine. “There is clearly a therapeutic potential to this.” Sanberg noted that for the process to work with Alzheimer’s it has to work with older brains. “There is clearly therapeutic potential in humans, but there are a lot of hurdles to overcome,” he said. “This is another demonstration of the potential for neural stem cells in brain disorders.”.

Dr. Nancy White Ph.D.- ” I’ve always been interested in health generally and in particular the brain, focusing on the balance of neurotransmitters. I often do quantitative EEG’s for assessment of my patients. I’m impressed with the concept of a natural product like stem cell nutrition that could help release adult stem cells from the bone mass where the body would have no objection and no rejection. I’ve tried stem cell nutrition for general health anti-aging. After taking it for a time, I fell more agile and my joints are far more flexible. I was astounded while doing yoga that I was suddenly able to bend over and touch my forehead to my knees. I haven’t been able to do that comfortably in probably twenty years. I noticed how much better my balance has become. I believe stem cell nutrition is responsible for these effects, because I certainly haven’t been trained extensively in yoga. Also since taking stem cell nutrition, I feel better and my skin is more moist and has a finer texture.

A bald friend of mine, who is also taking the stem cell nutrition, had several small cancers on top of his head. His doctor had removed one from his arm already, and his dermatologist set a date to remove those from his scalp. Before the appointment, my friend was shaving one morning and, looking in the mirror, saw that the cancers were all gone. They had disappeared within a few weeks of starting the stem cell nutrition and his skin is better overall. Also, his knee, which he’d strained playing tennis, was like new. Stem cell nutrition seems to go where the body’s priority is. You never know what the affect is going to be, but you notice something is changing. Another friend of mine seems to be dropping years. Her skin looks smoother and her face younger. After about six weeks on the stem cell nutrition, she looks like she’s ten years younger. A woman who gives her regular facials asked what she was doing, because her skin looked so much different. Stem cell nutrition is remarkable and could help anybody. Everybody should try it, because it’s natural and there are no risks. As we grow older in years, we still can have good health. That’s the ideal. Even if you don’t currently have a problem, stem cell nutrition is a preventative.”Dr. White holds a Ph. D. in Clinical Psychology, an MA in Behavioral Science, and a B.F.A. in Fine Arts, Magna Cum Laude. In addition, she is licensed in the State of Texas as a Psychologist , a Marriage and Family Therapist and as a Chemical Dependency Counselor.

Fernando Aguila, M.D. – “Due to a heavy patient load, I have recently found that I tire more easily, my legs are cramping, and by the time I get home, even my shoulders and rib cage hurt. I knew I had to find a way to increase my stamina, energy and vitality. A friend gave me information about stem cell nutrition and how it promotes the release of stem cells in the body. One of the components apparently promotes the migration of the stem cells to tissues or organs where regeneration and repair is needed most. My attention was drawn to the fact that it can increase energy, vitality, wellness, concentration, and much more. It sounded just like what I needed. Since then, I’ve heard reports of people experiencing excellent results in a number of different areas in their health. The improvements sounded dramatic. Because of all of their testimonies, I was willing to believe it could promote wellness in the human body.

I tried stem cell nutrition myself. After a day, of hard work, I realized I wasn’t tired at all, my legs were not aching, and I didn’t have any shoulder pain. I decided the stem cell nutrition must be working. I continued to take it, and was able to work so efficiently and steadily that one surgeon commented that I was moving like a ball of fire. Stem cell nutrition gives me support physically and mentally. I look forward to seeing what the major medical journals have to say about the studies being done with this new approach to wellness.”Fernando Aguila, M.D., graduated from the University of Santa Thomas in Manila , Philippines. He finished his internship at Cambridge City Hospital, Cambridge, MA and completed his residency at the New England Medical Center in Boston, MA. He obtained a fellowship in OB-GYN anesthesia at the Brigham and Women’s Hospital in Boston and a fellowship in cardio-thoracic anesthesia at the Cleveland Clinic Foundation in Cleveland, OH.

Christian Drapeau is America’s best known advocate for Adult Stem Cell science health applications and the founder of the field of Stem Cell Nutrition. He holds a BS in Neurophysiology from McGill University and a Master of Science in Neurology and Neurosurgery from the Montreal Neurological Institute.

One particular stem cell enhancers that was studied was found to contain a polysaccharide fraction that was shown to stimulate the migration of Natural Killer (NK) cells out of the blood into tissues. The same polysaccharide fraction was also shown to strongly stimulate the activation of NK cells. NK cells play the very important role in the body of identifying aberrant or defective cells and eliminating them. NK cells are especially known for their ability to detect and destroy virally infected cells and cells undergoing uncontrolled cellular division. The same polysaccharide fraction was also shown to stimulate macrophage activity. Macrophages constitute the front line of the immune system. They first detect an infection or the presence of bacteria or virally infected cells, and they then call for a full immune response. Adult Stem Cell Nutritional Enhancer also contains a significant concentration of chlorophyll and phycocyanin, the blue pigment in AFA. Phycocyanin has strong anti-inflammatory properties and therefore can assist the immune system.

The release of stem cells from the bone marrow and their migration to tissues is a natural process that happens everyday.Stem cell enhancers simply support that natural process and tips the balance toward health everyday. It does not do anything that the body does not already do everyday. So far, no instances of cancer or any similar problem have ever been observed when using in vivo natural release of stem cells from the bone marrow.

Each day, stem cells in the bone marrow evolve to produce red blood cells, white blood cells, and platelets. These mature cells are then released into the bloodstream where they perform their vital life-supporting functions. When bone marrow stem cell activity is interfered with, diseases such as anemia (red blood cell deficit), neutropenia (specialized white blood cell deficit), or thrombocytopenia (platelet deficit) are often diagnosed. Any one of these conditions can cause death if not corrected.

Scientists have long known that folic acid, vitamin B12, and iron are required for bone marrow stem cells to differentiate into mature red blood cells. Vitamin D has been shown to be crucial in the formation of immune cells, whereas carnosine has demonstrated a remarkable ability to rejuvenate cells approaching senescence and extend cellular life span.

Other studies of foods such as blueberries show this fruit can prevent and even reverse cell functions that decline as a result of normal aging. Blueberry extract has been shown to increase neurogenesis in the aged rat brain. Green tea compounds have been shown to inhibit the growth of tumor cells, while possibly providing protection against normal cellular aging.

Based on these findings, scientists are now speculating that certain nutrients could play important roles in maintaining the healthy renewal of replacement stem cells in the brain, blood, and other tissues. It may be possible, according to these scientists, to use certain nutrient combinations in the treatment of conditions that warrant stem cell replacement

These studies demonstrate for the first time that various natural compounds can promote the proliferation of human bone marrow cells and human stem cells. While these studies were done in vitro, they provide evidence that readily available nutrients may confer a protective effect against today’s epidemic of age-related bone marrow degeneration.

Dr. Robert Sampson, MD on stem cell nutrition – “… we have a product that has been shown and demonstrated in the patent to increase the level of adult circulating stem cells by up to 30%. It seems to me we’re having a great opportunity here to optimize the body’s natural ability to create health.”Recent scientific developments have revealed that stem cells derived from the bone marrow, travel throughout the body, and act to support optimal organ and tissue function. Stem cell enhancers supports the natural role of adult stem cells. Stem cell enhancer are typically derived from certain edible algae that grows in fresh water.

The possibility that a decline in the numbers or plasticity of stem cell populations contributes to aging and age-related disease is suggested by recent findings. The remarkable plasticity of stem cells suggests that endogenous or transplanted stem cells can be tweaked’ in ways that will allow them to replace lost or dysfunctional cell populations in diseases ranging from neurodegenerative and hematopoietic disorders to diabetes and cardiovascular disease.

As you age, the number and quality of stem cells that circulate in your body gradually decrease, leaving your body more susceptible to injury and other age-related health challenges. Just as antioxidants are important to protect your cells from free radical damage, stem cell nutrition is equally important to support your stem cells in maintaining proper organ and tissue functioning in your body.

A fundamental breakthrough in our understanding of nervous system development was the identification of multipotent neural stem cells (neurospheres) about ten years ago. Dr. Weiss and colleagues showed that EGF (epidermal growth factor) dependent stem cells could be harvested from different brain regions at different developmental stages and that these could be maintained over multiple passages in vitro. This initial finding has lead to an explosion of research on stem cells, their role in normal development and their potential therapeutic uses. Many investigators have entered this field and the progress made has been astounding.

How does an increase in the number of circulating stem cells lead to optimal health?Circulating stem cells can reach various organs and become cells of that organ, helping such organ regain and maintain optimal health. Recent studies have suggested that the number of circulating stem cells is a key factor; the higher the number of circulating stem cells the greater is the ability of the body at healing itself. Scientific interest in adult stem cells has centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. Adult stem cells are already being used clinically to treat many diseases. These include as reparative treatments with various cancers, autoimmune disease such as multiple sclerosis, lupus and arthritis, anemias including sickle cells anemia and immunodeficiencies. Adult stem cells are also being used to treat patients by formation of cartilage, growing new corneas to restore sight to blind patients, treatments for stroke, and several groups are using adult stem cells to repair damage after heart attacks. Early clinical trials have shown initial success in patient treatments for Parkinsons disease and spinal cord injury. The first FDA approved trial to treat juvenile diabetes in human patients is ready to begin at Harvard Medical School, using adult stem cells. An advantage of using adult stem cells is that in most cases, the patients own stem cells can be used for the treatment, circumventing the problems of immune rejection, and without tumor formation.

Why do we hear much in the news about embryonic stem cells and very little about adult stem cells?The first human embryonic stem cells were grown in vitro, in a petri dish, in the mid 1990s. Rapidly, scientists were successful at growing them for many generations and to trigger their differentiation into virtually any kind of cells, i.e. brain cells, heart cells, liver cells, bone cells, pancreatic cells, etc. When scientists tried growing adult stem cells, the endeavor was met with less success, as adult stem cells were difficult to grow in vitro for more than a few generations. This led to the idea that embryonic stem cells have more potential than adult stem cells. In addition, the ethical concerns linked to the use of embryonic stem cells have led to a disproportionate representation of embryonic stem cells in the media. But recent developments over the past 2-3 years have established that adult stem cells have capabilities comparable to embryonic stem cells in the human body, not in the test tube. Many studies have indicated that simply releasing stem cells from the bone marrow can help support the body’s natural process for renewal of tissues and organs.

The bone marrow constantly produces stem cells for the entire life of an individual. Stem cells released by the bone marrow are responsible for the constant renewal of red blood cells and lymphocytes (immune cells). A 25-30% increase in the number of circulating stem cells is well within physiological range and does not constitute stress on the bone marrow environment. The amount of active bone marrow amounts to about 2,600 g (5.7 lbs), with about 1.5 trillion marrow cells. Stem cells that do not reach any tissue or become blood cells return to the bone marrow.

Effectiveness of stem cell “enhancers” was demonstrated in a triple-blind study. Volunteers rested for one hour before establishing baseline levels. After the first blood samples, volunteers were given stem cell “enhancers”or placebo. Thereafter, blood samples were taken at 30, 60 and 120 minutes after taking the consumables. The number of circulating stem cells was quantified by analyzing the blood samples using Fluorescence-Activated Cell Sorting (FACS). Consumption of stem cell “enhancers” triggered a significant 25-30% increase in the number of circulating stem cells.

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Can Stem Cell Plant-Based be an Alternative to Embryonic …